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dc.contributor.authorRoti, Giovanni
dc.contributor.authorStegmaier, Kimberly
dc.date.accessioned2013-05-07T15:58:05Z
dc.date.issued2012
dc.identifier.citationRoti, Giovanni, and Kimberly Stegmaier. 2012. Genetic and proteomic approaches to identify cancer drug targets. British Journal of Cancer 106: 254-261.en_US
dc.identifier.issn0007-0920en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10611733
dc.description.abstractWhile target-based small-molecule discovery has taken centre-stage in the pharmaceutical industry, there are many cancer-promoting proteins not easily addressed with a traditional target-based screening approach. In order to address this problem, as well as to identify modulators of biological states in the absence of knowing the protein target of the state switch, alternative phenotypic screening approaches, such as gene expression-based and high-content imaging, have been developed. With this renewed interest in phenotypic screening, however, comes the challenge of identifying the binding protein target(s) of small-molecule hits. Emerging technologies have the potential to improve the process of target identification. In this review, we discuss the application of genomic (gene expression-based), genetic (short hairpin RNA and open reading frame screening), and proteomic approaches to protein target identification.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/bjc.2011.543en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262130/pdf/en_US
dash.licenseLAA
dc.subjectdrug discoveryen_US
dc.subjectprotein target identificationen_US
dc.subjectchemical genomicsen_US
dc.subjectchemical proteomicsen_US
dc.subjectsmall-molecule library screeningen_US
dc.subjectcancer drug targetsen_US
dc.titleGenetic and Proteomic Approaches to Identify Cancer Drug Targetsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBritish Journal of Canceren_US
dash.depositing.authorStegmaier, Kimberly
dc.date.available2013-05-07T15:58:05Z
dc.identifier.doi10.1038/bjc.2011.543*
dash.contributor.affiliatedRoti, Giovanni
dash.contributor.affiliatedStegmaier, Kimberly


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