Show simple item record

dc.contributor.authorLeuschner, Florian
dc.contributor.authorRobbins, Clinton
dc.contributor.authorIwamoto, Yoshiko
dc.contributor.authorThompson, Brian
dc.contributor.authorCarlson, Alicia L.
dc.contributor.authorHeidt, Timo
dc.contributor.authorLasitschka, Felix
dc.contributor.authorEtzrodt, Martin
dc.contributor.authorWaterman, Peter
dc.contributor.authorWaring, Michael T.
dc.contributor.authorChicoine, Adam T.
dc.contributor.authorvan der Laan, Anja M.
dc.contributor.authorNiessen, Hans W.M.
dc.contributor.authorPiek, Jan J.
dc.contributor.authorRubin, Barry B.
dc.contributor.authorButany, Jagdish
dc.contributor.authorKatus, Hugo A.
dc.contributor.authorMurphy, Sabina A.
dc.contributor.authorPittet, Mikael J.
dc.contributor.authorLin, Charles P.
dc.contributor.authorDutta, Partha
dc.contributor.authorCourties, Gabriel P
dc.contributor.authorWei, Ying
dc.contributor.authorGorbatov, Rostic
dc.contributor.authorMajmudar, Maulik D
dc.contributor.authorStone, James Robert
dc.contributor.authorMorrow, David Andrew
dc.contributor.authorSabatine, Marc Steven
dc.contributor.authorVinegoni, Claudio
dc.contributor.authorMoskowitz, Michael Arthur
dc.contributor.authorLibby, Peter
dc.contributor.authorSwirski, Filip K.
dc.contributor.authorWeissleder, Ralph
dc.contributor.authorNahrendorf, Matthias
dc.date.accessioned2013-05-08T19:36:42Z
dc.date.issued2012
dc.identifier.citationDutta, Partha, Gabriel Courties, Ying Wei, Florian Leuschner, Rostic Gorbatov, Clinton Robbins, Yoshiko Iwamoto, et al. 2012. Myocardial infarction accelerates atherosclerosis. Nature 487(7407): 325-329.en_US
dc.identifier.issn0028-0836en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10612854
dc.description.abstractDuring progression of atherosclerosis, myeloid cells destabilize lipid-rich plaque in the arterial wall and cause its rupture, thus triggering myocardial infarction and stroke. Survivors of acute coronary syndromes have a high risk of recurrent events for unknown reasons. Here we show that the systemic response to ischemic injury aggravates chronic atherosclerosis. After myocardial infarction or stroke, apoE\(^{−/−}\) mice developed larger atherosclerotic lesions with a more advanced morphology. This disease acceleration persisted over many weeks and was associated with markedly increased monocyte recruitment. When seeking the source of surplus monocytes in plaque, we found that myocardial infarction liberated hematopoietic stem and progenitor cells from bone marrow niches via sympathetic nervous system signaling. The progenitors then seeded the spleen yielding a sustained boost in monocyte production. These observations provide new mechanistic insight into atherogenesis and provide a novel therapeutic opportunity to mitigate disease progression.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/nature11260en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3401326/pdf/en_US
dash.licenseLAA
dc.titleMyocardial Infarction Accelerates Atherosclerosisen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalNatureen_US
dash.depositing.authorWeissleder, Ralph
dc.date.available2013-05-08T19:36:42Z
dc.identifier.doi10.1038/nature11260*
dash.authorsorderedfalse
dash.contributor.affiliatedMajmudar, Maulik
dash.contributor.affiliatedGorbatov, Rostic
dash.contributor.affiliatedWei, Ying
dash.contributor.affiliatedMoskowitz, Michael
dash.contributor.affiliatedPittet, Mikael
dash.contributor.affiliatedCourties, Gabriel
dash.contributor.affiliatedLin, Charles
dash.contributor.affiliatedDutta, Partha
dash.contributor.affiliatedMorrow, David
dash.contributor.affiliatedStone, James
dash.contributor.affiliatedSabatine, Marc
dash.contributor.affiliatedVinegoni, Claudio
dash.contributor.affiliatedWeissleder, Ralph
dash.contributor.affiliatedSwirski, Filip
dash.contributor.affiliatedLibby, Peter
dash.contributor.affiliatedNahrendorf, Matthias


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record