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dc.contributor.authorGrad, Yonatan Hagai
dc.contributor.authorGodfrey, Paul
dc.contributor.authorCerquiera, Gustavo C.
dc.contributor.authorMariani-Kurkdjian, Patricia
dc.contributor.authorGouali, Malika
dc.contributor.authorBingen, Edouard
dc.contributor.authorShea, Terrence P.
dc.contributor.authorHaas, Brian J.
dc.contributor.authorGriggs, Allison
dc.contributor.authorYoung, Sarah
dc.contributor.authorZeng, Qiandong
dc.contributor.authorLipsitch, Marc
dc.contributor.authorWaldor, Matthew K
dc.contributor.authorWeill, François-Xavier
dc.contributor.authorWortman, Jennifer R.
dc.contributor.authorHanage, William P.
dc.date.accessioned2013-05-08T20:09:14Z
dc.date.issued2013
dc.identifier.citationGrad, Yonatan H., Paul Godfrey, Gustavo C. Cerquiera, Patricia Mariani-Kurkdjian, Malika Gouali, Edouard Bingen, Terrence P. Shea, et al. 2013. Comparative genomics of recent shiga toxin-producing Escherichia coli O104:H4: short-term evolution of an emerging pathogen. mBio 4(1): e00452-12.en_US
dc.identifier.issn2150-7511en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10612874
dc.description.abstractThe large outbreak of diarrhea and hemolytic uremic syndrome (HUS) caused by Shiga toxin-producing Escherichia coli O104:H4 in Europe from May to July 2011 highlighted the potential of a rarely identified E. coli serogroup to cause severe disease. Prior to the outbreak, there were very few reports of disease caused by this pathogen and thus little known of its diversity and evolution. The identification of cases of HUS caused by E. coli O104:H4 in France and Turkey after the outbreak and with no clear epidemiological links raises questions about whether these sporadic cases are derived from the outbreak. Here, we report genome sequences of five independent isolates from these cases and results of a comparative analysis with historical and 2011 outbreak isolates. These analyses revealed that the five isolates are not derived from the outbreak strain; however, they are more closely related to the outbreak strain and each other than to isolates identified prior to the 2011 outbreak. Over the short time scale represented by these closely related organisms, the majority of genome variation is found within their mobile genetic elements: none of the nine O104:H4 isolates compared here contain the same set of plasmids, and their prophages and genomic islands also differ. Moreover, the presence of closely related HUS-associated E. coli O104:H4 isolates supports the contention that fully virulent O104:H4 isolates are widespread and emphasizes the possibility of future food-borne E. coli O104:H4 outbreaks.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Microbiologyen_US
dc.relation.isversionofdoi:10.1128/mBio.00452-12en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3551546/pdf/en_US
dash.licenseLAA
dc.titleComparative Genomics of Recent Shiga Toxin-Producing Escherichia coli O104:H4: Short-Term Evolution of an Emerging Pathogenen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalmBioen_US
dash.depositing.authorLipsitch, Marc
dc.date.available2013-05-08T20:09:14Z
dc.identifier.doi10.1128/mBio.00452-12*
dash.authorsorderedfalse
dash.contributor.affiliatedGrad, Yonatan
dash.contributor.affiliatedHanage, William
dash.contributor.affiliatedWaldor, Matthew
dash.contributor.affiliatedLipsitch, Marc


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