The Spectrum of Podoplanin Expression in Encapsulating Peritoneal Sclerosis

DSpace/Manakin Repository

The Spectrum of Podoplanin Expression in Encapsulating Peritoneal Sclerosis

Citable link to this page


Title: The Spectrum of Podoplanin Expression in Encapsulating Peritoneal Sclerosis
Author: Braun, Niko; Alscher, M. Dominik; Latus, Joerg; Edenhofer, Ilka; Kimmel, Martin; Biegger, Dagmar; Lindenmeyer, Maja; Cohen, Clemens D.; Wüthrich, Rudolf P.; Segerer, Stephan; Reimold, Fabian Raoul; Alper, Seth Leo; Fritz, Peter

Note: Order does not necessarily reflect citation order of authors.

Citation: Braun, Niko, M. Dominik Alscher, Peter Fritz, Joerg Latus, Ilka Edenhofer, Fabian Raoul Reimold, Seth Leo Alper, et al. 2012. The spectrum of podoplanin expression in encapsulating peritoneal sclerosis. PLoS ONE 7(12): e53382.
Full Text & Related Files:
Abstract: Encapsulating peritoneal sclerosis (EPS) is a life threatening complication of peritoneal dialysis (PD). Podoplanin is a glycoprotein expressed by mesothelial cells, lymphatic endothelial cells, and myofibroblasts in peritoneal biopsies from patients with EPS. To evaluate podoplanin as a marker of EPS we measured podoplanin mRNA and described the morphological patterns of podoplanin-positive cells in EPS. Included were 20 peritoneal biopsies from patients with the diagnosis of EPS (n = 5), patients on PD without signs of EPS (n = 5), and control patients (uremic patients not on PD, n = 5, non-uremic patients n = 5). EPS patient biopsies revealed significantly elevated levels of podoplanin mRNA (p<0.05). In 24 peritoneal biopsies from patients with EPS, podoplanin and smooth muscle actin (SMA) were localized by immunohistochemistry. Four patterns of podoplanin distribution were distinguishable. The most common pattern (8 of 24) consisted of organized, longitudinal layers of podoplanin-positive cells and vessels in the fibrotic zone (“organized” pattern). 7 of 24 biopsies demonstrated a diffuse distribution of podoplanin-positive cells, accompanied by occasional, dense clusters of podoplanin-positive cells. Five biopsies exhibited a mixed pattern, with some diffuse areas and some organized areas ("mixed"). These contained cuboidal podoplanin-positive cells within SMA-negative epithelial structures embedded in extracellular matrix. Less frequently observed was the complete absence of, or only focal accumulations of podoplanin-positive fibroblasts outside of lymphatic vessels (podoplanin “low”, 4 of 24 biopsies). Patients in this group exhibited a lower index of systemic inflammation and a longer symptomatic period than in EPS patients with biopsies of the "mixed" type (p<0.05). In summary we confirm the increased expression of podoplanin in EPS, and distinguish EPS biopsies according to different podoplanin expression patterns which are associated with clinical parameters. Podoplanin might serve as a useful adjunct to the morphological workup of peritoneal biopsies.
Published Version: doi:10.1371/journal.pone.0053382
Other Sources:
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at
Citable link to this page:
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)


Search DASH

Advanced Search