Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis

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Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis

Show simple item record Maslova, Ekaterina Strøm, Marin Olsen, Sjurdur F. Halldorsson, Thorhallur I. 2013-05-09T15:57:19Z 2013
dc.identifier.citation Maslova, Ekaterina, Marin Strøm, Sjurdur F. Olsen, and Thorhallur I. Halldorsson. 2013. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS ONE 8(2): e57261. en_US
dc.identifier.issn 1932-6203 en_US
dc.description.abstract Background: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. Objective: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. Methods: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. Results: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. Conclusion: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development. en_US
dc.language.iso en_US en_US
dc.publisher Public Library of Science en_US
dc.relation.isversionof doi:10.1371/journal.pone.0057261 en_US
dc.relation.hasversion en_US
dash.license LAA
dc.subject Medicine en_US
dc.subject Clinical Immunology en_US
dc.subject Allergy and Hypersensitivity en_US
dc.subject Clinical Research Design en_US
dc.subject Cohort Studies en_US
dc.subject Longitudinal Studies en_US
dc.subject Prospective Studies en_US
dc.subject Survey Research en_US
dc.subject Epidemiology en_US
dc.subject Pediatric Epidemiology en_US
dc.subject Nutrition en_US
dc.subject Obstetrics and Gynecology en_US
dc.subject Pregnancy en_US
dc.subject Pediatrics en_US
dc.subject Pulmonology en_US
dc.subject Asthma en_US
dc.subject Pediatric Pulmonology en_US
dc.title Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal PLoS ONE en_US Olsen, Sjurdur F. 2013-05-09T15:57:19Z

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