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dc.contributor.authorMaslova, Ekaterina
dc.contributor.authorStrøm, Marin
dc.contributor.authorOlsen, Sjurdur F.
dc.contributor.authorHalldorsson, Thorhallur I.
dc.date.accessioned2013-05-09T15:57:19Z
dc.date.issued2013
dc.identifier.citationMaslova, Ekaterina, Marin Strøm, Sjurdur F. Olsen, and Thorhallur I. Halldorsson. 2013. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS ONE 8(2): e57261.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10612954
dc.description.abstractBackground: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. Objective: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. Methods: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. Results: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. Conclusion: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0057261en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584110/pdf/en_US
dash.licenseLAA
dc.subjectMedicineen_US
dc.subjectClinical Immunologyen_US
dc.subjectAllergy and Hypersensitivityen_US
dc.subjectClinical Research Designen_US
dc.subjectCohort Studiesen_US
dc.subjectLongitudinal Studiesen_US
dc.subjectProspective Studiesen_US
dc.subjectSurvey Researchen_US
dc.subjectEpidemiologyen_US
dc.subjectPediatric Epidemiologyen_US
dc.subjectNutritionen_US
dc.subjectObstetrics and Gynecologyen_US
dc.subjectPregnancyen_US
dc.subjectPediatricsen_US
dc.subjectPulmonologyen_US
dc.subjectAsthmaen_US
dc.subjectPediatric Pulmonologyen_US
dc.titleConsumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitisen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorOlsen, Sjurdur F.
dc.date.available2013-05-09T15:57:19Z
dc.identifier.doi10.1371/journal.pone.0057261*
dash.contributor.affiliatedMaslova, Ekaterina
dash.contributor.affiliatedOlsen, Sjurdur


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