dc.contributor.author | Maslova, Ekaterina | |
dc.contributor.author | Strøm, Marin | |
dc.contributor.author | Olsen, Sjurdur F. | |
dc.contributor.author | Halldorsson, Thorhallur I. | |
dc.date.accessioned | 2013-05-09T15:57:19Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Maslova, Ekaterina, Marin Strøm, Sjurdur F. Olsen, and Thorhallur I. Halldorsson. 2013. Consumption of artificially-sweetened soft drinks in pregnancy and risk of child asthma and allergic rhinitis. PLoS ONE 8(2): e57261. | en_US |
dc.identifier.issn | 1932-6203 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10612954 | |
dc.description.abstract | Background: Past evidence has suggested a role of artificial sweeteners in allergic disease; yet, the evidence has been inconsistent and unclear. Objective: To examine relation of intake of artificially-sweetened beverages during pregnancy with child asthma and allergic rhinitis at 18 months and 7 years. Methods: We analyzed data from 60,466 women enrolled during pregnancy in the prospective longitudinal Danish National Birth Cohort between 1996 and 2003. At the 25th week of gestation we administered a validated Food Frequency Questionnaire which asked in detail about intake of artificially-sweetened soft drinks. At 18 months, we evaluated child asthma using interview data. We also assessed asthma and allergic rhinitis through a questionnaire at age 7 and by using national registries. Current asthma was defined as self-reported asthma diagnosis and wheeze in the past 12 months. We examined the relation between intake of artificially-sweetened soft drinks and child allergic disease outcomes and present here odds ratios with 95% CI comparing daily vs. no intake. Results: At 18 months, we found that mothers who consumed more artificially-sweetened non-carbonated soft drinks were 1.23 (95% CI: 1.13, 1.33) times more likely to report a child asthma diagnosis compared to non-consumers. Similar results were found for child wheeze. Consumers of artificially-sweetened carbonated drinks were more likely to have a child asthma diagnosis in the patient (1.30, 95% CI: 1.01, 1.66) and medication (1.13, 95% CI: 0.98, 1.29) registry, as well as self-reported allergic rhinitis (1.31, 95% CI: 0.98, 1.74) during the first 7 years of follow-up. We found no associations for sugar-sweetened soft drinks. Conclusion: Carbonated artificially-sweetened soft drinks were associated with registry-based asthma and self-reported allergic rhinitis, while early childhood outcomes were related to non-carbonated soft drinks. These results suggest that consumption of artificially-sweetened soft drinks during pregnancy may play a role in offspring allergic disease development. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | Public Library of Science | en_US |
dc.relation.isversionof | doi:10.1371/journal.pone.0057261 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3584110/pdf/ | en_US |
dash.license | LAA | |
dc.subject | Medicine | en_US |
dc.subject | Clinical Immunology | en_US |
dc.subject | Allergy and Hypersensitivity | en_US |
dc.subject | Clinical Research Design | en_US |
dc.subject | Cohort Studies | en_US |
dc.subject | Longitudinal Studies | en_US |
dc.subject | Prospective Studies | en_US |
dc.subject | Survey Research | en_US |
dc.subject | Epidemiology | en_US |
dc.subject | Pediatric Epidemiology | en_US |
dc.subject | Nutrition | en_US |
dc.subject | Obstetrics and Gynecology | en_US |
dc.subject | Pregnancy | en_US |
dc.subject | Pediatrics | en_US |
dc.subject | Pulmonology | en_US |
dc.subject | Asthma | en_US |
dc.subject | Pediatric Pulmonology | en_US |
dc.title | Consumption of Artificially-Sweetened Soft Drinks in Pregnancy and Risk of Child Asthma and Allergic Rhinitis | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | PLoS ONE | en_US |
dash.depositing.author | Olsen, Sjurdur F. | |
dc.date.available | 2013-05-09T15:57:19Z | |
dc.identifier.doi | 10.1371/journal.pone.0057261 | * |
dash.contributor.affiliated | Maslova, Ekaterina | |
dash.contributor.affiliated | Olsen, Sjurdur | |