Show simple item record

dc.contributor.authorMwimanzi, Philip
dc.contributor.authorMarkle, Tristan J
dc.contributor.authorMartin, Eric
dc.contributor.authorOgata, Yoko
dc.contributor.authorKuang, Xiaomei T
dc.contributor.authorTokunaga, Michiyo
dc.contributor.authorMahiti, Macdonald
dc.contributor.authorPereyra, Florencia M.
dc.contributor.authorMiura, Toshiyuki
dc.contributor.authorWalker, Bruce David
dc.contributor.authorBrumme, Zabrina L
dc.contributor.authorBrockman, Mark A
dc.contributor.authorUeno, Takamasa
dc.date.accessioned2013-05-09T18:15:55Z
dc.date.issued2013
dc.identifier.citationMwimanzi, Philip, Tristan J. Markle, Eric Martin, Yoko Ogata, Xiaomei T. Kuang, Michiyo Tokunaga, Macdonald Mahiti, and et al. 2013. Attenuation of multiple Nef functions in HIV-1 elite controllers. Retrovirology 10:1.en_US
dc.identifier.issn1742-4690en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10613651
dc.description.abstractBackground: Impaired HIV-1 Gag, Pol, and Env function has been described in elite controllers (EC) who spontaneously suppress plasma viremia to < 50 RNA copies/mL; however, activity of the accessory protein Nef remains incompletely characterized. We examined the ability of 91 Nef clones, isolated from plasma of 45 EC and 46 chronic progressors (CP), to down-regulate HLA class I and CD4, up-regulate HLA class II invariant chain (CD74), enhance viral infectivity, and stimulate viral replication in PBMC. Results: In general, EC Nef clones were functional; however, all five activities were significantly lower in EC compared to CP. Nef clones from HLA-B*57-expressing EC exhibited poorer CD4 down-regulation function compared to those from non-B*57 EC, and the number of EC-specific B*57-associated Nef polymorphisms correlated inversely with 4 of 5 Nef functions in these individuals. Conclusion: Results indicate that decreased HIV-1 Nef function, due in part to host immune selection pressures, may be a hallmark of the EC phenotype.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1742-4690-10-1en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3564836/pdf/en_US
dash.licenseLAA
dc.subjectHIV-1en_US
dc.subjectNefen_US
dc.subjectHuman Leukocyte Antigen (HLA) class Ien_US
dc.subjectHLA-B*57en_US
dc.subjectelite controllersen_US
dc.subjectimmune escapeen_US
dc.subjectreplication capacityen_US
dc.titleAttenuation of Multiple Nef Functions in HIV-1 Elite Controllersen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalRetrovirologyen_US
dash.depositing.authorWalker, Bruce David
dc.date.available2013-05-09T18:15:55Z
dc.identifier.doi10.1186/1742-4690-10-1*
dash.authorsorderedfalse
dash.contributor.affiliatedPereyra, F
dash.contributor.affiliatedWalker, Bruce


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record