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dc.contributor.authorBlüher, Matthias
dc.contributor.authorRudich, Assaf
dc.contributor.authorKlöting, Nora
dc.contributor.authorGolan, Rachel
dc.contributor.authorHenkin, Yaakov
dc.contributor.authorRubin, Eitan
dc.contributor.authorSchwarzfuchs, Dan
dc.contributor.authorGepner, Yftach
dc.contributor.authorStampfer, Meir Jonathan
dc.contributor.authorFiedler, Martin
dc.contributor.authorThiery, Joachim
dc.contributor.authorStumvoll, Michael
dc.contributor.authorShai, Iris
dc.date.accessioned2013-05-09T18:24:42Z
dc.date.issued2012
dc.identifier.citationBlüher, Matthias, Assaf Rudich, Nora Klöting, Rachel Golan, Yaakov Henkin, Eitan Rubin, Dan Schwarzfuchs, et al. 2012. Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35(2): 342-349.en_US
dc.identifier.issn0149-5992en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10613654
dc.description.abstractObjective: Long-term dietary intervention frequently induces a rapid weight decline followed by weight stabilization/regain. Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial weight regain. Research design and methods: We analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) of low-fat, Mediterranean, or low-carbohydrate diets for weight loss. Results: We identified two distinct patterns: Pattern A includes biomarkers (insulin, triglycerides, leptin, chemerin, monocyte chemoattractant protein 1, and retinol-binding protein 4) whose dynamics tightly correspond to changes in body weight, with the trend during the weight loss phase (months 0–6) going in the opposite direction to that in the weight maintenance/regain phase (months 7–24) (P < 0.05 between phases, all biomarkers). Pattern B includes biomarkers (high molecular weight adiponectin, HDL cholesterol [HDL-C], high-sensitivity C-reactive protein [hsCRP], fetuin-A, progranulin, and vaspin) that displayed a continued, cumulative improvement (P < 0.05 compared with baseline, all biomarkers) throughout the intervention. These patterns were consistent across sex, diabetic groups, and diet groups, although the magnitude of change varied. Hierarchical analysis suggested similar clusters, revealing that the dynamic of leptin (pattern A) was most closely linked to weight change and that the dynamic of hsCRP best typified pattern B. Conclusions: hsCRP, HDL-C, adiponectin, fetuin-A, progranulin, and vaspin levels display a continued long-term improvement despite partial weight regain. This may likely reflect either a delayed effect of the initial weight loss or a continuous beneficial response to switching to healthier dietary patterns.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Diabetes Associationen_US
dc.relation.isversionofdoi:10.2337/dc11-1267en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263919/pdf/en_US
dash.licenseLAA
dc.subjectpathophysiologyen_US
dc.subjectcomplicationsen_US
dc.titleTwo Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Interventionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalDiabetes Careen_US
dash.depositing.authorStampfer, Meir Jonathan
dc.date.available2013-05-09T18:24:42Z
dc.identifier.doi10.2337/dc11-1267*
dash.authorsorderedfalse
dash.contributor.affiliatedShai, Iris
dash.contributor.affiliatedStampfer, Meir


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