Two Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Intervention

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Two Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Intervention

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dc.contributor.author Blüher, Matthias
dc.contributor.author Rudich, Assaf
dc.contributor.author Klöting, Nora
dc.contributor.author Golan, Rachel
dc.contributor.author Henkin, Yaakov
dc.contributor.author Rubin, Eitan
dc.contributor.author Schwarzfuchs, Dan
dc.contributor.author Gepner, Yftach
dc.contributor.author Stampfer, Meir Jonathan
dc.contributor.author Fiedler, Martin
dc.contributor.author Thiery, Joachim
dc.contributor.author Stumvoll, Michael
dc.contributor.author Shai, Iris
dc.date.accessioned 2013-05-09T18:24:42Z
dc.date.issued 2012
dc.identifier.citation Blüher, Matthias, Assaf Rudich, Nora Klöting, Rachel Golan, Yaakov Henkin, Eitan Rubin, Dan Schwarzfuchs, et al. 2012. Two patterns of adipokine and other biomarker dynamics in a long-term weight loss intervention. Diabetes Care 35(2): 342-349. en_US
dc.identifier.issn 0149-5992 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:10613654
dc.description.abstract Objective: Long-term dietary intervention frequently induces a rapid weight decline followed by weight stabilization/regain. Here, we sought to identify adipokine biomarkers that may reflect continued beneficial effects of dieting despite partial weight regain. Research design and methods: We analyzed the dynamics of fasting serum levels of 12 traditional metabolic biomarkers and novel adipokines among 322 participants in the 2-year Dietary Intervention Randomized Controlled Trial (DIRECT) of low-fat, Mediterranean, or low-carbohydrate diets for weight loss. Results: We identified two distinct patterns: Pattern A includes biomarkers (insulin, triglycerides, leptin, chemerin, monocyte chemoattractant protein 1, and retinol-binding protein 4) whose dynamics tightly correspond to changes in body weight, with the trend during the weight loss phase (months 0–6) going in the opposite direction to that in the weight maintenance/regain phase (months 7–24) (P < 0.05 between phases, all biomarkers). Pattern B includes biomarkers (high molecular weight adiponectin, HDL cholesterol [HDL-C], high-sensitivity C-reactive protein [hsCRP], fetuin-A, progranulin, and vaspin) that displayed a continued, cumulative improvement (P < 0.05 compared with baseline, all biomarkers) throughout the intervention. These patterns were consistent across sex, diabetic groups, and diet groups, although the magnitude of change varied. Hierarchical analysis suggested similar clusters, revealing that the dynamic of leptin (pattern A) was most closely linked to weight change and that the dynamic of hsCRP best typified pattern B. Conclusions: hsCRP, HDL-C, adiponectin, fetuin-A, progranulin, and vaspin levels display a continued long-term improvement despite partial weight regain. This may likely reflect either a delayed effect of the initial weight loss or a continuous beneficial response to switching to healthier dietary patterns. en_US
dc.language.iso en_US en_US
dc.publisher American Diabetes Association en_US
dc.relation.isversionof doi:10.2337/dc11-1267 en_US
dc.relation.hasversion http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263919/pdf/ en_US
dash.license LAA
dc.subject pathophysiology en_US
dc.subject complications en_US
dc.title Two Patterns of Adipokine and Other Biomarker Dynamics in a Long-Term Weight Loss Intervention en_US
dc.type Journal Article en_US
dc.description.version Version of Record en_US
dc.relation.journal Diabetes Care en_US
dash.depositing.author Stampfer, Meir Jonathan
dc.date.available 2013-05-09T18:24:42Z

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