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dc.contributor.authorZhong, Wei-de
dc.contributor.authorQin, Guo-qiang
dc.contributor.authorDai, Qi-shan
dc.contributor.authorHan, Zhao-dong
dc.contributor.authorChen, Shan-ming
dc.contributor.authorLing, Xiao-hui
dc.contributor.authorFu, Xin
dc.contributor.authorChen, Jia-hong
dc.contributor.authorChen, Xi-bin
dc.contributor.authorLin, Zhuo-yuan
dc.contributor.authorDeng, Ye-han
dc.contributor.authorHe, Hui-chan
dc.contributor.authorWu, Chin-Lee
dc.contributor.authorWu, Shulin
dc.contributor.authorCai, Chao
dc.date.accessioned2013-05-13T18:47:34Z
dc.date.issued2012
dc.identifier.citationZhong, Wei-de, Guo-qiang Qin, Qi-shan Dai, Zhao-dong Han, Shan-ming Chen, Xiao-hui Ling, Xin Fu, et al. 2012. SOXs in human prostate cancer: Implication as progression and prognosis factors. BMC Cancer 12:248.en_US
dc.identifier.issn1471-2407en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10622922
dc.description.abstractBackground: SOX genes play an important role in a number of developmental processes. Potential roles of SOXs have been demonstrated in various neoplastic tissues as tumor suppressors or promoters depending on tumor status and types. The aim of this study was to investigate the involvement of SOXs in the progression and prognosis of human prostate cancer (PCa). Methods: The gene expression changes of SOXs in human PCa tissues compared with non-cancerous prostate tissues was detected using gene expression microarray, and confirmed by real-time quantitative reverse transcriptase-polymerase chain reaction (QRT-PCR) analysis and immunohositochemistry. The roles of these genes in castration resistance were investigated in LNCaP xenograft model of PCa. Results: The microarray analysis identified three genes (SOX7, SOX9 and SOX10) of SOX family that were significantly dis-regulated in common among four PCa specimens. Consistent with the results of the microarray, differential mRNA and protein levels of three selected genes were found in PCa tissues by QRT-PCR analysis and immunohistochemistry. Additionally, we found that the immunohistochemical staining scores of SOX7 in PCa tissues with higher serum PSA level (P = 0.02) and metastasis (P = 0.03) were significantly lower than those with lower serum PSA level and without metastasis; the increased SOX9 protein expression was frequently found in PCa tissues with higher Gleason score (P = 0.02) and higher clinical stage (P < 0.0001); the down-regulation of SOX10 tend to be found in PCa tissues with higher serum PSA levels (P = 0.03) and advanced pathological stage (P = 0.01). Moreover, both univariate and multivariate analyses showed that the down-regulation of SOX7 and the up-regulation of SOX9 were independent predictors of shorter biochemical recurrence-free survival. Furthermore, we discovered that SOX7 was significantly down-regulated and SOX9 was significantly up-regulated during the progression to castration resistance. Conclusions: Our data offer the convince evidence that the dis-regulation of SOX7, SOX9 and SOX10 may be associated with the aggressive progression of PCa. SOX7 and SOX9 may be potential markers for prognosis in PCa patients. Interestingly, the down-regulation of SOX7 and the up-regulation of SOX9 may be important mechanisms for castration-resistant progression of PCa.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/1471-2407-12-248en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3583167/pdf/en_US
dash.licenseLAA
dc.subjectProstate canceren_US
dc.subjectSOXen_US
dc.subjectClinicopathological featureen_US
dc.subjectBiochemical recurrence-free survivalen_US
dc.titleSOXs in Human Prostate Cancer: Implication as Progression and Prognosis Factorsen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMC Canceren_US
dash.depositing.authorWu, Chin-Lee
dc.date.available2013-05-13T18:47:34Z
dc.identifier.doi10.1186/1471-2407-12-248*
dash.authorsorderedfalse
dash.contributor.affiliatedWu, Chin-Lee
dash.contributor.affiliatedWu, Shulin


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