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dc.contributor.authorRyter, Stefan W.
dc.contributor.authorChoi, Augustine M.K.
dc.date.accessioned2013-05-13T20:00:49Z
dc.date.issued2013
dc.identifier.citationRyter, Stefan W., and Augustine M. K. Choi. 2013. Carbon monoxide: Present and future indications for a medical gas. Korean Journal of Internal Medicine 28(2): 123-140.en_US
dc.identifier.issn1226-3303en_US
dc.identifier.issn2005-6648en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10622981
dc.description.abstractGaseous molecules continue to hold new promise in molecular medicine as experimental and clinical therapeutics. The low molecular weight gas carbon monoxide (CO), and similar gaseous molecules (e.g., \(H_2S\), nitric oxide) have been implicated as potential inhalation therapies in inflammatory diseases. At high concentration, CO represents a toxic inhalation hazard, and is a common component of air pollution. CO is also produced endogenously as a product of heme degradation catalyzed by heme oxygenase enzymes. CO binds avidly to hemoglobin, causing hypoxemia and decreased oxygen delivery to tissues at high concentrations. At physiological concentrations, CO may have endogenous roles as a signal transduction molecule in the regulation of neural and vascular function and cellular homeostasis. CO has been demonstrated to act as an effective anti-inflammatory agent in preclinical animal models of inflammation, acute lung injury, sepsis, ischemia/reperfusion injury, and organ transplantation. Additional experimental indications for this gas include pulmonary fibrosis, pulmonary hypertension, metabolic diseases, and preeclampsia. The development of chemical CO releasing compounds constitutes a novel pharmaceutical approach to CO delivery with demonstrated effectiveness in sepsis models. Current and pending clinical evaluation will determine the usefulness of this gas as a therapeutic in human disease.en_US
dc.language.isoen_USen_US
dc.publisherThe Korean Association of Internal Medicineen_US
dc.relation.isversionofdoi:10.3904/kjim.2013.28.2.123en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604600/pdf/en_US
dash.licenseLAA
dc.subjectAcute lung injuryen_US
dc.subjectCarbon monoxideen_US
dc.subjectHeme oxygenase (decyclizing)en_US
dc.subjectReperfusion injuryen_US
dc.subjectSepsisen_US
dc.titleCarbon Monoxide: Present and Future Indications for a Medical Gasen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalKorean Journal of Internal Medicineen_US
dash.depositing.authorChoi, Augustine M.K.
dc.date.available2013-05-13T20:00:49Z
dc.identifier.doi10.3904/kjim.2013.28.2.123*
dash.contributor.affiliatedChoi, Augustine M.K.
dash.contributor.affiliatedRyter, Stefan W.


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