Intestinal Microbiota, Probiotics and Mental Health: From Metchnikoff to Modern Advances: Part I – Autointoxication Revisited

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Intestinal Microbiota, Probiotics and Mental Health: From Metchnikoff to Modern Advances: Part I – Autointoxication Revisited

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Title: Intestinal Microbiota, Probiotics and Mental Health: From Metchnikoff to Modern Advances: Part I – Autointoxication Revisited
Author: Bested, Alison C; Logan, Alan C; Selhub, Eva Michelle

Note: Order does not necessarily reflect citation order of authors.

Citation: Bested, Alison C., Alan C. Logan, and Eva M. Selhub. 2013. Intestinal microbiota, probiotics and mental health: From Metchnikoff to modern advances: Part I – Autointoxication revisited. Gut Pathogens 5(1): 5.
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Abstract: Mental health disorders, depression in particular, have been described as a global epidemic. Research suggests that a variety of lifestyle and environmental changes may be driving at least some portion of the increased prevalence. One area of flourishing research involves the relationship between the intestinal microbiota (as well as the related functional integrity of the gastrointestinal tract) and mental health. In order to appreciate the recent scientific gains in this area, and its potential future directions, it is critical to review the history of the topic. Probiotic administration (e.g. Lactobacillus) and fecal microbiota transfer for conditions associated with depression and anxiety is not a new concept. Here, in the first of a 3-part series, we begin by reviewing the origins of the contemporary research, providing a critical appraisal of what has become a revisionist history of the controversial term ‘autointoxication’. We argue that legitimate interests in the gut-brain-microbiota connection were obscured for decades by its association with a narrow historical legacy. Historical perspectives provide a very meaningful context to the current state of the contemporary research as outlined in parts II and III.
Published Version: doi:10.1186/1757-4749-5-5
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3607857/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10622994
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