Prevalence, Distribution, and Risk Factor Correlates of High Thoracic Periaortic Fat in the Framingham Heart Study

View/ Open
Author
Pedley, Alison
Massaro, Joseph M.
Corsini, Erin M.
Murabito, Joanne M.
Published Version
https://doi.org/10.1161/JAHA.112.004200Metadata
Show full item recordCitation
Britton, Kathryn A., Alison Pedley, Joseph M. Massaro, Erin M. Corsini, Joanne M. Murabito, Udo Hoffmann, and Caroline S. Fox. 2012. Prevalence, distribution, and risk factor correlates of high thoracic periaortic fat in the Framingham Heart Study. Journal of the American Heart Association 1(6): e004200.Abstract
Background: Thoracic periaortic adipose tissue (TAT) is associated with atherosclerosis and cardiovascular disease (CVD) risk factors and may play a role in obesity‐mediated vascular disease. We sought to determine the prevalence, distribution, and risk factor correlates of high TAT. Methods and Results: Participants from the Framingham Heart Study (n=3246, 48% women, mean age 51.1 years) underwent multidetector computed tomography; high TAT and visceral adipose tissue (VAT) were defined on the basis of sex‐specific 90th percentiles in a healthy referent sample. The prevalence of high TAT was 38.1% in women and 35.7% in men. Among individuals without high VAT, 10.1% had high TAT. After adjustment for age and VAT, both women and men with high TAT in the absence of high VAT were older and had a higher prevalence of CVD (P<0.0001) compared with those without high TAT. In addition, men in this group were more likely to be smokers (P=0.02), whereas women were more likely to have low high‐density lipoprotein cholesterol (P=0.005). Conclusions: Individuals in our community‐based sample with high TAT in the absence of high VAT were characterized by an adverse cardiometabolic profile. This adipose tissue phenotype may identify a subset of individuals with distinct metabolic characteristics.Other Sources
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540666/pdf/Terms of Use
This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAACitable link to this page
http://nrs.harvard.edu/urn-3:HUL.InstRepos:10623005
Collections
- HMS Scholarly Articles [17767]
Contact administrator regarding this item (to report mistakes or request changes)