Evidence of Widespread Selection on Standing Variation in Europe at Height-Associated SNPs

DSpace/Manakin Repository

Evidence of Widespread Selection on Standing Variation in Europe at Height-Associated SNPs

Citable link to this page

 

 
Title: Evidence of Widespread Selection on Standing Variation in Europe at Height-Associated SNPs
Author: Turchin, Michael C.; Chiang, Charleston W. K.; Palmer, Cameron Douglas; Sankararaman, Sriram; Reich, David Emil; Hirschhorn, Joel Naom; GIANT Consortium

Note: Order does not necessarily reflect citation order of authors.

Citation: Turchin, Michael C., Charleston W. K. Chiang, Cameron Douglas Palmer, Sriram Sankararaman, David Emil Reich, GIANT consortium, and Joel Noam Hirschhorn. 2012. Evidence of widespread selection on standing variation in Europe at height-associated SNPs. Nature Genetics 44(9): 1015-1019.
Full Text & Related Files:
Abstract: Strong signatures of positive selection at newly arising genetic variants are well-documented in humans, but this form of selection may not be widespread in recent human evolution. Because many human traits are highly polygenic and partly determined by common, ancient genetic variation, an alternative model for rapid genetic adaptation has been proposed: weak selection acting on many pre-existing (standing) genetic variants, or polygenic adaptation. By studying height, a classic polygenic trait, we demonstrate the first human signature of widespread selection on standing variation. We show that frequencies of alleles associated with increased height, both at known loci and genome-wide, are systematically elevated in Northern Europeans compared with Southern Europeans \((p<4.3×10^{−4})\). This pattern mirrors intra-European height differences and is not confounded by ancestry or other ascertainment biases. The systematic frequency differences are consistent with the presence of widespread weak selection (selection coefficients \(~10^{−3}–10^{−5}\) per allele) rather than genetic drift alone \((p<10^{−15})\).
Published Version: doi:10.1038/ng.2368
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3480734/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10623009
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters