Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development

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Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development

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Title: Asymmetric Requirement of Surface Epithelial β-Catenin During the Upper and Lower Jaw Development
Author: Sun, Ye; Teng, Ian; Huo, Randi; Rosenfeld, Michael G; Olson, Lorin E; Li, Xiaokun; Li, Xue

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Citation: Sun, Ye, Ian Teng, Randi Huo, Michael G. Rosenfeld, Lorin E. Olson, Xiaokun Li, and Xue Li. 2012. Asymmetric requirement of surface epithelial β-catenin during the upper and lower jaw development. Developmental Dynamics 241(4): 663-674.
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Abstract: Background: Intercellular communication between epithelial and mesenchymal cells is central to mammalian craniofacial development. β-catenin is the gateway of canonical Wnt signaling, one of the major evolutionarily conserved cell–cell communication pathways in metazoa. In this study, we report an unexpected stage- and tissue-specific function of β-catenin during mammalian jaw development. Results: Using a unique mouse genetic tool, we have discovered that epithelial β-catenin is essential for lower jaw formation, while attenuation of β-catenin is required for proper upper jaw development. Changes in β-catenin in vivo alter major epithelial Fgf8, Bmp4, Shh, and Edn1 signals, resulting in partial transcriptional reprogramming of the neural crest-derived mesenchyme, the primary source of jawbones. Conclusions: The Wnt/β-catenin signal coordinates expression of multiple epithelial signals and has stage-specific asymmetric functions during mammalian upper and lower jaw development. In addition, these findings suggest that evolutionary changes of the canonical Wnt/β-catenin signaling pathway may lead to innovation of jaws.
Published Version: doi:10.1002/dvdy.23755
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3308359/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10628434
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