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dc.contributor.authorDiGangi, Julia
dc.contributor.authorGuffanti, Guia
dc.contributor.authorMcLaughlin, Katie Anne
dc.contributor.authorKoenen, Karestan C
dc.date.accessioned2013-06-05T16:13:56Z
dc.date.issued2013
dc.identifier.citationDiGangi, Julia, Guia Guffanti, Katie A McLaughlin, and Karestan C Koenen. 2013. Considering trauma exposure in the context of genetics studies of posttraumatic stress disorder: a systematic review. Biology of Mood & Anxiety Disorders 3:2.en_US
dc.identifier.issn2045-5380en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10718377
dc.description.abstractBackground: Posttraumatic stress disorder (PTSD) is a debilitating anxiety disorder. Surveys of the general population suggest that while 50-85% of Americans will experience a traumatic event in their lifetime, only 2-50% will develop PTSD. Why some individuals develop PTSD following trauma exposure while others remain resilient is a central question in the field of trauma research. For more than half a century, the role of genetic influences on PTSD has been considered as a potential vulnerability factor. However, despite the exponential growth of molecular genetic studies over the past decade, limited progress has been made in identifying true genetic variants for PTSD. Methods: In an attempt to aid future genome wide association studies (GWAS), this paper presents a systematic review of 28 genetic association studies of PTSD. Inclusion criteria required that 1) all participants were exposed to Criterion A traumatic events, 2) polymorphisms of relevant genes were genotyped and assessed in relation to participants’ PTSD status, 3) quantitative methods were used, and 4) articles were published in English and in peer-reviewed journals. In the examination of these 28 studies, particular attention was given to variables related to trauma exposure (e.g. number of traumas, type of trauma). Results: Results indicated that most articles did not report on the GxE interaction in the context of PTSD or present data on the main effects of E despite having data available. Furthermore, some studies that did consider the GxE interaction had significant findings, underscoring the importance of examining how genotypes can modify the effect of trauma on PTSD. Additionally, results indicated that only a small number of genes continue to be studied and that there were marked differences in methodologies across studies, which subsequently limited robust conclusions. Conclusions: As trauma exposure is a necessary condition for the PTSD diagnosis, this paper identifies gaps in the current literature as well as provides recommendations for how future GWAS studies can most effectively incorporate trauma exposure data in both the design and analysis phases of studies.en_US
dc.language.isoen_USen_US
dc.publisherBioMed Centralen_US
dc.relation.isversionofdoi:10.1186/2045-5380-3-2en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3598333/pdf/en_US
dash.licenseLAA
dc.subjectPosttraumatic stress disorderen_US
dc.subjectTraumaen_US
dc.subjectGeneticsen_US
dc.subjectGenome-wide association studiesen_US
dc.subjectGene–environment interactionen_US
dc.titleConsidering Trauma Exposure in the Context of Genetics Studies of Posttraumatic Stress Disorder: A Systematic Reviewen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBiology of Mood & Anxiety Disordersen_US
dash.depositing.authorMcLaughlin, Katie Anne
dc.date.available2013-06-05T16:13:56Z
dc.identifier.doi10.1186/2045-5380-3-2*
dash.contributor.affiliatedMcLaughlin, Katie


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