ER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

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ER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway

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dc.contributor.author Denic, Vladimir
dc.contributor.author Dötsch, Volker
dc.contributor.author Sinning, Irmgard
dc.date.accessioned 2013-06-14T18:45:22Z
dc.date.issued 2013-06-14
dc.identifier.citation Denic, Vladimir, Volker Dötsch, and Irmgard Sinning. Forthcoming. ER targeting and insertion of tail-anchored membrane proteins by the GET pathway. Cold Spring Harbor Perspectives in Biology. en_US
dc.identifier.issn 1943-0264 en_US
dc.identifier.uri http://nrs.harvard.edu/urn-3:HUL.InstRepos:10752116
dc.description.abstract Hundreds of eukaryotic membrane proteins are anchored to membranes by a single transmembrane domain at their C-terminus. Many of these tail-anchored (TA) proteins are post-translationally targeted to the endoplasmic reticulum (ER) membrane for insertion by the Guided-Entry of TA protein insertion (GET) pathway. In recent years most of the components of this conserved pathway have been biochemically and structurally characterized. Get3 is the pathway targeting factor that utilizes nucleotide-linked conformational changes to mediate the delivery of TA proteins between the GET pre-targeting machinery in the cytosol and the transmembrane pathway components in the ER. Here we focus on the mechanism of the yeast GET pathway and make a speculative analogy between its membrane insertion step and the ATPase-driven cycle of ABC transporters. en_US
dc.description.sponsorship Molecular and Cellular Biology en_US
dc.language.iso en_US en_US
dc.publisher Cold Spring Harbor Laboratory Press en_US
dc.relation.isversionof doi:10.1101/cshperspect.a013334 en_US
dash.license OAP
dc.title ER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathway en_US
dc.type Journal Article en_US
dc.description.version Accepted Manuscript en_US
dc.relation.journal Cold Spring Harbor Perspectives in Biology en_US
dash.depositing.author Denic, Vladimir
dc.date.available 2013-06-14T18:45:22Z

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