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dc.contributor.authorDenic, Vladimir
dc.contributor.authorDötsch, Volker
dc.contributor.authorSinning, Irmgard
dc.date.accessioned2013-06-14T18:45:22Z
dc.date.issued2013-06-14
dc.identifier.citationDenic, Vladimir, Volker Dötsch, and Irmgard Sinning. Forthcoming. ER targeting and insertion of tail-anchored membrane proteins by the GET pathway. Cold Spring Harbor Perspectives in Biology.en_US
dc.identifier.issn1943-0264en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10752116
dc.description.abstractHundreds of eukaryotic membrane proteins are anchored to membranes by a single transmembrane domain at their C-terminus. Many of these tail-anchored (TA) proteins are post-translationally targeted to the endoplasmic reticulum (ER) membrane for insertion by the Guided-Entry of TA protein insertion (GET) pathway. In recent years most of the components of this conserved pathway have been biochemically and structurally characterized. Get3 is the pathway targeting factor that utilizes nucleotide-linked conformational changes to mediate the delivery of TA proteins between the GET pre-targeting machinery in the cytosol and the transmembrane pathway components in the ER. Here we focus on the mechanism of the yeast GET pathway and make a speculative analogy between its membrane insertion step and the ATPase-driven cycle of ABC transporters.en_US
dc.description.sponsorshipMolecular and Cellular Biologyen_US
dc.language.isoen_USen_US
dc.publisherCold Spring Harbor Laboratory Pressen_US
dc.relation.isversionofdoi:10.1101/cshperspect.a013334en_US
dash.licenseOAP
dc.titleER Targeting and Insertion of Tail-Anchored Membrane Proteins by the GET Pathwayen_US
dc.typeJournal Articleen_US
dc.description.versionAccepted Manuscripten_US
dc.relation.journalCold Spring Harbor Perspectives in Biologyen_US
dash.depositing.authorDenic, Vladimir
dc.date.available2013-06-14T18:45:22Z
dc.identifier.doi10.1101/cshperspect.a013334*
dash.contributor.affiliatedDenic, Vladimir


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