A Portrait of the GET Pathway as a Surprisingly Complicated Young Man

DSpace/Manakin Repository

A Portrait of the GET Pathway as a Surprisingly Complicated Young Man

Citable link to this page

 

 
Title: A Portrait of the GET Pathway as a Surprisingly Complicated Young Man
Author: Denic, Vladimir
Citation: Denic, Vladimir. 2012. A portrait of the GET pathway as a surprisingly complicated young man. Trends in Biochemical Sciences 37(10): 411-417.
Full Text & Related Files:
Abstract: Many eukaryotic membrane proteins have a single C-terminal transmembrane domain that anchors them to a variety of organelles in secretory and endocytic pathways. These tail-anchored (TA) proteins are post-translationally inserted into the endoplasmic reticulum by molecular mechanisms that have long remained mysterious. This review describes how, in just the past 5 years, intense research by a handful of laboratories has led to identification of all the key components of one such mechanism, the guided entry of TA proteins (GET) pathway, which is conserved from yeast to man. The GET pathway is both surprisingly complicated and yet more experimentally tractable than most other membrane insertion mechanisms, and is rapidly revealing new fundamental concepts in membrane protein biogenesis.
Published Version: doi:10.1016/j.tibs.2012.07.004
Other Sources: http://www.ncbi.nlm.nih.gov/pubmed/22951232
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10752117
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters