The Structure of Genealogies in the Presence of Purifying Selection: a "Fitness-Class Coalescent"

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The Structure of Genealogies in the Presence of Purifying Selection: a "Fitness-Class Coalescent"

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Title: The Structure of Genealogies in the Presence of Purifying Selection: a "Fitness-Class Coalescent"
Author: Walczak, Aleksandra M.; Nicolaisen, Lauren Elisabeth; Plotkin, Joshua B.; Desai, Michael M

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Citation: Walczak, Aleksandra M., Lauren E. Nicolaisen, Joshua B. Plotkin, and Michael M. Desai. 2012. The structure of genealogies in the presence of purifying selection: a "fitness-class coalescent." Genetics 190(2): 753-79.
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Abstract: Compared to a neutral model, purifying selection distorts the structure of genealogies and hence alters the patterns of sampled genetic variation. Although these distortions may be common in nature, our understanding of how we expect purifying selection to affect patterns of molecular variation remains incomplete. Genealogical approaches such as coalescent theory have proven difficult to generalize to situations involving selection at many linked sites, unless selection pressures are extremely strong. Here, we introduce an effective coalescent theory (a "fitness-class coalescent") to describe the structure of genealogies in the presence of purifying selection at many linked sites. We use this effective theory to calculate several simple statistics describing the expected patterns of variation in sequence data, both at the sites under selection and at linked neutral sites. Our analysis combines a description of the allele frequency spectrum in the presence of purifying selection with the structured coalescent approach of Kaplan et al. (1988), to trace the ancestry of individuals through the distribution of fitnesses within the population. We also derive our results using a more direct extension of the structured coalescent approach of Hudson and Kaplan (1994). We find that purifying selection leads to patterns of genetic variation that are related but not identical to a neutrally evolving population in which population size has varied in a specific way in the past.
Published Version: dx.doi.org/10.1534/genetics.111.134544
Other Sources: http://www.genetics.org/content/190/2/753.short
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:10859952
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