dc.contributor.author | Pichery, Céline | |
dc.contributor.author | Bellanger, Martine | |
dc.contributor.author | Zmirou-Navier, Denis | |
dc.contributor.author | Fréry, Nadine | |
dc.contributor.author | Cordier, Sylvaine | |
dc.contributor.author | Roue-LeGall, Anne | |
dc.contributor.author | Hartemann, Philippe | |
dc.contributor.author | Grandjean, Philippe | |
dc.date.accessioned | 2013-08-02T00:37:48Z | |
dc.date.issued | 2012 | |
dc.identifier | Quick submit: 2013-04-05T03:11:22-04:00 | |
dc.identifier.citation | Pichery, Céline, Martine Bellanger, Denis Zmirou-Navier, Nadine Fréry, Sylvaine Cordier, Anne Roue-LeGall, Philippe Hartemann, and Philippe Grandjean. 2012. Economic evaluation of health consequences of prenatal methylmercury exposure in France. Environmental Health 11: 53. | en_US |
dc.identifier.issn | 1476-069X | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:10908608 | |
dc.description.abstract | Background: Evidence of a dose–response relationship between prenatal exposure to methylmercury (MeHg) and neurodevelopmental consequences in terms of IQ reduction, makes it possible to evaluate the economic
consequences of MeHg exposures. Objective: To perform an economic evaluation of annual national benefits of reduction of the prenatal MeHg exposure in France. Methods: We used data on hair-Hg concentrations in French women of childbearing age (18–45 years) from a national sample of 126 women and from two studies conducted in coastal regions (n= 161and n=503). A linear dose response function with a slope of 0.465 IQ point reduction per μg/g increase in hair-Hg concentration was used, along with a log transformation of the exposure scale, where a doubling of exposure was associated with a loss of 1.5 IQ points. The costs calculations utilized an updated estimate of €\(_{2008}\) 17,363 per IQ point decrement, with three hypothetical exposure cut-off points (hair-Hg of 0.58, 1.0, and 2.5 μg/g). Results: Because of higher exposure levels of women in coastal communities, the annual economic impacts based on these data were greater than those using the national data, i.e. € 1.62 billion (national), and € 3.02 billion and € 2.51 billion (regional), respectively, with the linear model, and € 5.46 billion (national), and € 9.13 billion and € 8.17 billion (regional), with the log model, for exposures above 0.58 μg/g. Conclusions: These results emphasize that efforts to reduce MeHg exposures would have high social benefits by preventing the serious and lifelong consequences of neurodevelopmental deficits in children. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | BioMed Central | en_US |
dash.license | LAA | |
dc.title | Economic Evaluation of Health Consequences of Prenatal Methylmercury Exposure in France | en_US |
dc.type | Journal Article | en_US |
dc.date.updated | 2013-04-05T07:11:30Z | |
dc.description.version | Version of Record | en_US |
dc.rights.holder | Pichery C, Bellanger M, Zmirou-Navier D, Fréry N, Cordier S, Roue-LeGall A, Hartemann P, Grandjean P. | |
dc.relation.journal | Environmental Health | en_US |
dash.depositing.author | Grandjean, Philippe | |
dc.date.available | 2013-08-02T00:37:48Z | |
dc.identifier.doi | 10.1186/1476-069X-11-53 | |
dash.contributor.affiliated | Grandjean, Philippe | |