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dc.contributor.authorLudvigsson, J F
dc.contributor.authorFall, Katja
dc.contributor.authorMontgomery, S
dc.date.accessioned2013-08-05T21:35:28Z
dc.date.issued2012
dc.identifier.citationLudvigsson, J F, K Fall, and S Montgomery. 2012. Risk of prostate cancer in a population-based cohort of men with coeliac disease. British Journal of Cancer 106(1): 217-221.en_US
dc.identifier.issn0007-0920en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10919707
dc.description.abstractBackground: Prostate cancer (PC) is a leading cause of fatal cancer in men in developed countries. Coeliac disease (CD) has previously been linked to a raised cancer risk, and changes in some exposures following a CD diagnosis might hypothetically raise PC risk. Methods: We identified 10 995 patients with CD who had undergone a small intestinal biopsy in 1969–2007. Statistics Sweden then identified 54 233 age-matched male reference individuals from the general population. PC data were obtained from the Swedish Cancer Register. Hazard ratios (HRs) for PC were estimated using Cox regression analysis. Results: During follow-up, 185 individuals with CD (expected n=200) had an incident diagnosis of PC. This corresponds to a HR of 0.92 (0.79–1.08) (with 95% confidence interval) and an absolute risk reduction of 15/100 000 person-years among those with CD. An increased risk was not observed even when identification of PC began 5 years after biopsy. Conclusion: Our conclusion is that a CD diagnosis does not represent an increased risk for PC.en_US
dc.language.isoen_USen_US
dc.publisherNature Publishing Groupen_US
dc.relation.isversionofdoi:10.1038/bjc.2011.536en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3251872/pdf/en_US
dash.licenseLAA
dc.subjectcoeliac diseaseen_US
dc.subjectcohort studyen_US
dc.subjectinflammationen_US
dc.subjectprostate canceren_US
dc.titleRisk of prostate cancer in a population-based cohort of men with coeliac diseaseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBritish Journal of Canceren_US
dash.depositing.authorFall, Katja
dc.date.available2013-08-05T21:35:28Z
dc.identifier.doi10.1038/bjc.2011.536*
dash.contributor.affiliatedFall, Katja


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