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dc.contributor.authorRobinson, Christopher
dc.contributor.authorZhou, Xiaohong
dc.contributor.authorRajaiya, Jayabarathy
dc.contributor.authorYousuf, Mohammad Abu
dc.contributor.authorSingh, Gurdeep
dc.contributor.authorDeSerres, Joshua J.
dc.contributor.authorWalsh, Michael P.
dc.contributor.authorWong, Sallene
dc.contributor.authorSeto, Donald
dc.contributor.authorDyer, David W.
dc.contributor.authorChodosh, James
dc.contributor.authorJones, Morris S.
dc.date.accessioned2013-08-23T17:31:16Z
dc.date.issued2013
dc.identifier.citationRobinson, Christopher M., Xiaohong Zhou, Jayabarathy Rajaiya, Mohammad Abu Yousuf, Gurdeep Singh, Joshua J. DeSerres, Michael P. Walsh, et al. 2013. Predicting the next eye pathogen: Analysis of a novel adenovirus. mBio 4(2): e00595-12.en_US
dc.identifier.issn2150-7511en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10978157
dc.description.abstractFor DNA viruses, genetic recombination, addition, and deletion represent important evolutionary mechanisms. Since these genetic alterations can lead to new, possibly severe pathogens, we applied a systems biology approach to study the pathogenicity of a novel human adenovirus with a naturally occurring deletion of the canonical penton base Arg-Gly-Asp (RGD) loop, thought to be critical to cellular entry by adenoviruses. Bioinformatic analysis revealed a new highly recombinant species D human adenovirus (HAdV-D60). A synthesis of in silico and laboratory approaches revealed a potential ocular tropism for the new virus. In vivo, inflammation induced by the virus was dramatically greater than that by adenovirus type 37, a major eye pathogen, possibly due to a novel alternate ligand, Tyr-Gly-Asp (YGD), on the penton base protein. The combination of bioinformatics and laboratory simulation may have important applications in the prediction of tissue tropism for newly discovered and emerging viruses.en_US
dc.language.isoen_USen_US
dc.publisherAmerican Society of Microbiologyen_US
dc.relation.isversionofdoi:10.1128/mBio.00595-12en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3622935/pdf/en_US
dash.licenseLAA
dc.titlePredicting the Next Eye Pathogen: Analysis of a Novel Adenovirusen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalmBioen_US
dash.depositing.authorChodosh, James
dc.date.available2013-08-23T17:31:16Z
dc.identifier.doi10.1128/mBio.00595-12*
dash.authorsorderedfalse
dash.contributor.affiliatedRajaiya, Jaya
dash.contributor.affiliatedZhou, Xiaohong
dash.contributor.affiliatedRobinson, Christopher
dash.contributor.affiliatedSingh, Gurdeep
dash.contributor.affiliatedYousuf, Mohammad Abu
dash.contributor.affiliatedChodosh, James


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