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dc.contributor.advisorBuckner, Randy Lee
dc.contributor.authorVincent, Justin Lee
dc.date.accessioned2013-08-28T14:05:08Z
dc.date.issued2013-08-28
dc.date.submitted2013
dc.identifier.citationVincent, Justin Lee. 2013. Neural Correlates of Subjective Familiarity and Choice Bias during Episodic Memory Judgments. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11022en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:10984872
dc.description.abstractSuccessful recognition memory decisions depend on mnemonic and decision making processes that are computed by multiple, distributed brain areas. However, little is known about what computations these areas perform or how these areas are connected. Here, I collected behavioral and functional magnetic resonance imaging data from humans during the performance of an old-new recognition memory task with retrospective confidence judgments. Across runs, choice bias was successfully manipulated by providing rewards for correct responses that were either symmetric (equal reward for hits and correct rejections) or asymmetric (one response worth more than the other). Successful recognition memory was associated with activation in anterior prefrontal, parahippocampal, posterior cingulate, and parietal cortex. Resting state functional connectivity demonstrated that these brain areas are organized into two distinct networks. The first network includes parahippocampal cortex and angular gyrus. The second network includes lateral prefrontal cortex and intraparietal sulcus. The hippocampal-cortical network was most active during old vs. new decisions, did not differentiate hits from false alarms, and was differentially active during low confidence old and new judgments. In contrast, while the frontoparietal network was robustly activated by hits, it was not activated during either false alarms or low confidence old judgments. Thus, these two distinct networks can be distinguished by their relative connectivity to the medial temporal lobe vs. lateral prefrontal cortex and their responses during uncertain old judgments and errors. The choice bias manipulation had opposing effects on the parietal components of these networks, which further suggests these networks make distinct contributions to mnemonic decision making.en_US
dc.description.sponsorshipPsychologyen_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectPsychologyen_US
dc.subjectepisodic memoryen_US
dc.subjectfamiliarityen_US
dc.subjectfMRIen_US
dc.subjectfunctional connectivityen_US
dc.subjectparietal cortexen_US
dc.titleNeural Correlates of Subjective Familiarity and Choice Bias during Episodic Memory Judgmentsen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorVincent, Justin Lee
dc.date.available2013-08-28T14:05:08Z
thesis.degree.date2013en_US
thesis.degree.disciplinePsychologyen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberSchacter, Danielen_US
dc.contributor.committeeMemberAlvarez, Georgeen_US
dc.contributor.committeeMemberXu, Yaodaen_US
dash.contributor.affiliatedVincent, Justin Lee


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