dc.contributor.author | Madrigano, Jaime | |
dc.contributor.author | Kloog, Itai | |
dc.contributor.author | Goldberg, Robert | |
dc.contributor.author | Coull, Brent Andrew | |
dc.contributor.author | Mittleman, Murray A. | |
dc.contributor.author | Schwartz, Joel David | |
dc.date.accessioned | 2013-09-09T20:11:40Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Madrigano, Jaime, Itai Kloog, Robert Goldberg, Brent A. Coull, Murray A. Mittleman, and Joel Schwartz. 2013. Long-term exposure to pm2.5 and incidence of acute myocardial infarction. Environmental Health Perspectives 121(2): 192-196. | en_US |
dc.identifier.issn | 0091-6765 | en_US |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11011815 | |
dc.description.abstract | Background: A number of studies have shown associations between chronic exposure to particulate air pollution and increased mortality, particularly from cardiovascular disease, but fewer studies have examined the association between long-term exposure to fine particulate air pollution and specific cardiovascular events, such as acute myocardial infarction (AMI). Objective: We examined how long-term exposure to area particulate matter affects the onset of AMI, and we distinguished between area and local pollutants. Methods: Building on the Worcester Heart Attack Study, an ongoing community-wide investigation examining changes over time in myocardial infarction incidence in greater Worcester, Massachusetts, we conducted a case–control study of 4,467 confirmed cases of AMI diagnosed between 1995 and 2003 and 9,072 matched controls selected from Massachusetts resident lists. We used a prediction model based on satellite aerosol optical depth (AOD) measurements to generate both exposure to particulate matter ≤ 2.5 μm in diameter (PM\(_{2.5}\)) at the area level (10 × 10 km) and the local level (100 m) based on local land use variables. We then examined the association between area and local particulate pollution and occurrence of AMI. Results: An interquartile range (IQR) increase in area PM\(_{2.5}\) (0.59 μg/m\(^3\)) was associated with a 16% increase in the odds of AMI (95% CI: 1.04, 1.29). An IQR increase in total PM\(_{2.5}\) (area + local, 1.05 μg/m\(^3\)) was weakly associated with a 4% increase in the odds of AMI (95% CI: 0.96, 1.11). Conclusions: Residential exposure to PM\(_{2.5}\) may best be represented by a combination of area and local PM\(_{2.5}\), and it is important to consider spatial gradients within a single metropolitan area when examining the relationship between particulate matter exposure and cardiovascular events. | en_US |
dc.language.iso | en_US | en_US |
dc.publisher | National Institute of Environmental Health Sciences | en_US |
dc.relation.isversionof | doi:10.1289/ehp.1205284 | en_US |
dc.relation.hasversion | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569684/pdf/ | en_US |
dash.license | LAA | |
dc.subject | air pollution. | en_US |
dc.title | Long-term Exposure to \(PM_{2.5}\) and Incidence of Acute Myocardial Infarction | en_US |
dc.type | Journal Article | en_US |
dc.description.version | Version of Record | en_US |
dc.relation.journal | Environmental Health Perspectives | en_US |
dash.depositing.author | Coull, Brent Andrew | |
dc.date.available | 2013-09-09T20:11:40Z | |
dc.identifier.doi | 10.1289/ehp.1205284 | * |
dash.contributor.affiliated | Madrigano, Jaime | |
dash.contributor.affiliated | Coull, Brent | |
dash.contributor.affiliated | Mittleman, Murray | |
dash.contributor.affiliated | Schwartz, Joel | |
dc.identifier.orcid | 0000-0002-2557-150X | |