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dc.contributor.authorMadrigano, Jaime
dc.contributor.authorKloog, Itai
dc.contributor.authorGoldberg, Robert
dc.contributor.authorCoull, Brent Andrew
dc.contributor.authorMittleman, Murray A.
dc.contributor.authorSchwartz, Joel David
dc.date.accessioned2013-09-09T20:11:40Z
dc.date.issued2013
dc.identifier.citationMadrigano, Jaime, Itai Kloog, Robert Goldberg, Brent A. Coull, Murray A. Mittleman, and Joel Schwartz. 2013. Long-term exposure to pm2.5 and incidence of acute myocardial infarction. Environmental Health Perspectives 121(2): 192-196.en_US
dc.identifier.issn0091-6765en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11011815
dc.description.abstractBackground: A number of studies have shown associations between chronic exposure to particulate air pollution and increased mortality, particularly from cardiovascular disease, but fewer studies have examined the association between long-term exposure to fine particulate air pollution and specific cardiovascular events, such as acute myocardial infarction (AMI). Objective: We examined how long-term exposure to area particulate matter affects the onset of AMI, and we distinguished between area and local pollutants. Methods: Building on the Worcester Heart Attack Study, an ongoing community-wide investigation examining changes over time in myocardial infarction incidence in greater Worcester, Massachusetts, we conducted a case–control study of 4,467 confirmed cases of AMI diagnosed between 1995 and 2003 and 9,072 matched controls selected from Massachusetts resident lists. We used a prediction model based on satellite aerosol optical depth (AOD) measurements to generate both exposure to particulate matter ≤ 2.5 μm in diameter (PM\(_{2.5}\)) at the area level (10 × 10 km) and the local level (100 m) based on local land use variables. We then examined the association between area and local particulate pollution and occurrence of AMI. Results: An interquartile range (IQR) increase in area PM\(_{2.5}\) (0.59 μg/m\(^3\)) was associated with a 16% increase in the odds of AMI (95% CI: 1.04, 1.29). An IQR increase in total PM\(_{2.5}\) (area + local, 1.05 μg/m\(^3\)) was weakly associated with a 4% increase in the odds of AMI (95% CI: 0.96, 1.11). Conclusions: Residential exposure to PM\(_{2.5}\) may best be represented by a combination of area and local PM\(_{2.5}\), and it is important to consider spatial gradients within a single metropolitan area when examining the relationship between particulate matter exposure and cardiovascular events.en_US
dc.language.isoen_USen_US
dc.publisherNational Institute of Environmental Health Sciencesen_US
dc.relation.isversionofdoi:10.1289/ehp.1205284en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3569684/pdf/en_US
dash.licenseLAA
dc.subjectair pollution.en_US
dc.titleLong-term Exposure to \(PM_{2.5}\) and Incidence of Acute Myocardial Infarctionen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEnvironmental Health Perspectivesen_US
dash.depositing.authorCoull, Brent Andrew
dc.date.available2013-09-09T20:11:40Z
dc.identifier.doi10.1289/ehp.1205284*
dash.contributor.affiliatedMadrigano, Jaime
dash.contributor.affiliatedMittleman, Murray
dash.contributor.affiliatedSchwartz, Joel
dash.contributor.affiliatedCoull, Brent


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