Development, specification, and diversity of callosal projection neurons

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Development, specification, and diversity of callosal projection neurons

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Title: Development, specification, and diversity of callosal projection neurons
Author: Fame, Ryann M.; MacDonald, Jessica Linn; Macklis, Jeffrey Daniel

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Citation: Fame, Ryann M., Jessica L. MacDonald, and Jeffrey D. Macklis. 2011. “Development, specification, and diversity of callosal projection neurons.” Trends in Neurosciences 34 (1) (January): 41-50.
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Abstract: Callosal projection neurons (CPN) are a diverse population of neocortical projection neurons that connect the two hemispheres of the cerebral cortex via the corpus callosum. They play key roles in high-level associative connectivity, and have been implicated in cognitive syndromes of high-level associative dysfunction, such as autism spectrum disorders. CPN evolved relatively recently compared to other cortical neuron populations, and have undergone disproportionately large expansion from mouse to human. While much is known about the anatomical trajectory of developing CPN axons, and progress has been made in identifying cellular and molecular controls over midline crossing, only recently have molecular-genetic controls been identified that specify CPN populations, and help define CPN subpopulations. In this review, we discuss development, diversity, and evolution of CPN.
Published Version: doi:10.1016/j.tins.2010.10.002
Other Sources: http://hscrb.harvard.edu/sites/default/files/Macklis_Fame_Trends%20in%20Neurosciences_2011-01.pdf
Terms of Use: This article is made available under the terms and conditions applicable to Open Access Policy Articles, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#OAP
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11130516
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