The function of the Heg-CCM pathway in zebrafish heart development

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The function of the Heg-CCM pathway in zebrafish heart development

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Title: The function of the Heg-CCM pathway in zebrafish heart development
Author: Rosen, Jonathan Novick
Citation: Rosen, Jonathan Novick. 2013. The function of the Heg-CCM pathway in zebrafish heart development. Doctoral dissertation, Harvard University.
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Abstract: The Heart of glass-Cerebral Cavernous Malformation (Heg-CCM) pathway is essential for heart development in zebrafish and mouse. In zebrafish, mutants for the Heg-CCM genes ccm1, ccm2, and heg exhibit an extreme dilation of the heart chambers and inflow tract and completely lack blood circulation. The mechanisms by which this pathway regulates heart development are incompletely understood. Two major impediments to our knowledge are the paucity of genes known to participate in the Heg-CCM pathway and a lack of information about how the Heg-CCM pathway interacts with other signaling pathways in live embryos.
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11151537
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