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dc.contributor.advisorRubin, Eric Joseph
dc.contributor.authorZhang, Yanjia Jason
dc.date.accessioned2013-10-08T20:21:42Z
dash.embargo.terms2014-06-07en_US
dash.embargo.terms2014-06-07
dc.date.issued2013-10-08
dc.date.submitted2013
dc.identifier.citationZhang, Yanjia Jason. 2013. Turning the tide against TB: Remaking ineffective host defenses into mechanisms for tuberculosis control. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:10759en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11156782
dc.description.abstractMost antibiotics, including the drugs currently used for treating tuberculosis (TB), were first discovered as molecules that inhibit bacterial growth in laboratory culture conditions and later translated to infection models and clinical use. Mycobacterium tuberculosis (Mtb) has evolved specifically to survive in its human host, and it is in this infectious context that new drugs need to work. The host environment is characterized by a multitude of antimicrobial defenses induced by the immune system, and we can leverage these defenses to kill Mtb in vivo. Mtb employs a diverse set of responses to survive host defenses. By blocking these responses, we can make Mtb more susceptible to host immunity, turning these previously impotent defenses into effective strategies of immune control.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectMicrobiologyen_US
dc.subjectImmunologyen_US
dc.subjectMolecular biologyen_US
dc.subjectDrug Developmenten_US
dc.subjectInfectious Diseaseen_US
dc.subjectTuberculosisen_US
dc.subjectVirulenceen_US
dc.titleTurning the tide against TB: Remaking ineffective host defenses into mechanisms for tuberculosis controlen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorZhang, Yanjia Jason
dc.date.available2014-06-07T07:30:52Z
thesis.degree.date2013en_US
thesis.degree.disciplineBiological Sciences in Public Healthen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberGoldberg, Marciaen_US
dc.contributor.committeeMemberFortune, Sarahen_US
dc.contributor.committeeMemberBloom, Barryen_US
dc.contributor.committeeMemberKornfeld, Hardyen_US
dash.contributor.affiliatedZhang, Yanjia


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