Patterns of molecular evolution and epistasis on a genomic and genic scale

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Patterns of molecular evolution and epistasis on a genomic and genic scale

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Title: Patterns of molecular evolution and epistasis on a genomic and genic scale
Author: Jiang, Pan-Pan
Citation: Jiang, Pan-Pan. 2013. Patterns of molecular evolution and epistasis on a genomic and genic scale. Doctoral dissertation, Harvard University.
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Abstract: Epistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes or even chromosomes affecting global patterns of gene expression. It can also happen within a gene itself, with epistatic interactions between amino acids affecting gene expression and resultant phenotypes. I present three studies in two organisms to study this phenomenon on a global-genomic scale, and also on a local-genic scale.
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808
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