Patterns of molecular evolution and epistasis on a genomic and genic scale
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CitationJiang, Pan-Pan. 2013. Patterns of molecular evolution and epistasis on a genomic and genic scale. Doctoral dissertation, Harvard University.
AbstractEpistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes or even chromosomes affecting global patterns of gene expression. It can also happen within a gene itself, with epistatic interactions between amino acids affecting gene expression and resultant phenotypes. I present three studies in two organisms to study this phenomenon on a global-genomic scale, and also on a local-genic scale.
Citable link to this pagehttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808
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