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dc.contributor.advisorHartl, Daniel L.
dc.contributor.authorJiang, Pan-Pan
dc.date.accessioned2013-10-08T20:39:11Z
dc.date.issued2013-10-08
dc.date.submitted2013
dc.identifier.citationJiang, Pan-Pan. 2013. Patterns of molecular evolution and epistasis on a genomic and genic scale. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:10771en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11156808
dc.description.abstractEpistasis describes non-additive interactions which affect gene expression and phenotype. It can happen on multiple levels, including on a genomic level with interactions between genes or even chromosomes affecting global patterns of gene expression. It can also happen within a gene itself, with epistatic interactions between amino acids affecting gene expression and resultant phenotypes. I present three studies in two organisms to study this phenomenon on a global-genomic scale, and also on a local-genic scale.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectGeneticsen_US
dc.subjectEvolution & developmenten_US
dc.subjectdrug resistanceen_US
dc.subjectepistasisen_US
dc.subjectheterochromatinen_US
dc.subjectmalariaen_US
dc.subjectY chromosomeen_US
dc.titlePatterns of molecular evolution and epistasis on a genomic and genic scaleen_US
dc.typeThesis or Dissertationen_US
dc.date.available2013-10-08T20:39:11Z
thesis.degree.date2013en_US
thesis.degree.disciplineBiology, Organismic and Evolutionaryen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberExtavour, Cassandraen_US
dc.contributor.committeeMemberHoekstra, Hopien_US
dc.contributor.committeeMemberPringle, Anneen_US


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