Regulation of Behavioral Arousal in C. elegans

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Regulation of Behavioral Arousal in C. elegans

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Title: Regulation of Behavioral Arousal in C. elegans
Author: Choi, Seungwon
Citation: Choi, Seungwon. 2013. Regulation of Behavioral Arousal in C. elegans. Doctoral dissertation, Harvard University.
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Abstract: Animals undergo periods of behavioral quiescence and arousal in response to environmental, circadian, or developmental cues. During larval molts, C. elegans undergoes a period of profound behavioral quiescence termed lethargus. Locomotion quiescence during lethargus was abolished in mutants lacking a neuropeptide receptor (NPR-1), and was reduced in mutants lacking NPR-1 ligands (FLP-18 and -21). Wild type strains are polymorphic for the npr-1 gene, and their lethargus behavior varies correspondingly. Locomotion quiescence and arousal were mediated by decreased and increased secretion of an arousal neuropeptide (PDF-1) from central neurons. PDF receptors (PDFR-1) expressed in peripheral mechanosensory neurons enhanced touch-evoked calcium transients. Thus, a central circuit stimulates arousal from lethargus by enhancing the sensitivity of peripheral mechanosensory neurons in the body. These results define a circuit mechanism controlling a developmentally programmed form of quiescence.
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Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158244
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