Human Vascular Endothelium from Induced Pluripotent Stem Cells

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Human Vascular Endothelium from Induced Pluripotent Stem Cells

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Title: Human Vascular Endothelium from Induced Pluripotent Stem Cells
Author: Adams, William James
Citation: Adams, William James. 2013. Human Vascular Endothelium from Induced Pluripotent Stem Cells. Doctoral dissertation, Harvard University.
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Abstract: The vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-derived endothelial cells remains poorly understood.
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11158273
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