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dc.contributor.advisorGarcia-Cardena, Guillermo
dc.contributor.advisorSuo, Zhigang
dc.contributor.authorAdams, William James
dc.date.accessioned2013-10-09T01:43:22Z
dash.embargo.terms2015-06-07en_US
dash.embargo.terms2015-06-07
dc.date.issued2013-10-08
dc.date.submitted2013
dc.identifier.citationAdams, William James. 2013. Human Vascular Endothelium from Induced Pluripotent Stem Cells. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:10816en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11158273
dc.description.abstractThe vascular endothelium is a dynamic cellular interface that displays a unique phenotypic plasticity. This plasticity is critical for vascular function and when dysregulated is pathogenic in several diseases. The development of new human endothelial genotype-phenotype studies, personalized vascular medicine efforts and cell based regenerative therapies are limited by the unavailability of patient-specific endothelial cells. Induced pluripotent stem cells (iPSC) offer great promise as a new personalized source of endothelium; however, the reproducibility, fidelity and functionality of iPSC-derived endothelial cells remains poorly understood.en_US
dc.description.sponsorshipEngineering and Applied Sciencesen_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectBiomedical engineeringen_US
dc.subjectCellular biologyen_US
dc.subjectendotheliumen_US
dc.subjectinduced pluripotent stem cellsen_US
dc.titleHuman Vascular Endothelium from Induced Pluripotent Stem Cellsen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorAdams, William James
dc.date.available2015-06-08T07:30:33Z
thesis.degree.date2013en_US
thesis.degree.disciplineEngineering and Applied Sciencesen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberMooney, Daviden_US
dash.contributor.affiliatedAdams, William


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