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dc.contributor.authorHollister, Jesse D.
dc.contributor.authorArnold, Brian John
dc.contributor.authorSvedin, Elisabeth
dc.contributor.authorXue, Katherine Shaohua
dc.contributor.authorDilkes, Brian P.
dc.contributor.authorBomblies, Kirsten
dc.date.accessioned2013-10-09T16:41:44Z
dc.date.issued2012
dc.identifierQuick submit: 2013-07-03T15:41:00-04:00
dc.identifier.citationHollister, Jesse D., Brian J. Arnold, Elisabeth Svedin, Katherine S. Xue, Brian P. Dilkes, and Kirsten Bomblies. 2012. Genetic Adaptation Associated with Genome-Doubling in Autotetraploid Arabidopsis arenosa. Ed. Rodney Mauricio. PLoS Genetics 8 (12) (December 20): e1003093.en_US
dc.identifier.issn1553-7390en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11158278
dc.description.abstractGenome duplication, which results in polyploidy, is disruptive to fundamental biological processes. Genome duplications occur spontaneously in a range of taxa and problems such as sterility, aneuploidy, and gene expression aberrations are common in newly formed polyploids. In mammals, genome duplication is associated with cancer and spontaneous abortion of embryos. Nevertheless, stable polyploid species occur in both plants and animals. Understanding how natural selection enabled these species to overcome early challenges can provide important insights into the mechanisms by which core cellular functions can adapt to perturbations of the genomic environment. Arabidopsis arenosa includes stable tetraploid populations and is related to well-characterized diploids A. lyrata and A. thaliana. It thus provides a rare opportunity to leverage genomic tools to investigate the genetic basis of polyploid stabilization. We sequenced the genomes of twelve A. arenosa individuals and found signatures suggestive of recent and ongoing selective sweeps throughout the genome. Many of these are at genes implicated in genome maintenance functions, including chromosome cohesion and segregation, DNA repair, homologous recombination, transcriptional regulation, and chromatin structure. Numerous encoded proteins are predicted to interact with one another. For a critical meiosis gene, ASYNAPSIS1, we identified a non-synonymous mutation that is highly differentiated by cytotype, but present as a rare variant in diploid A. arenosa, indicating selection may have acted on standing variation already present in the diploid. Several genes we identified that are implicated in sister chromatid cohesion and segregation are homologous to genes identified in a yeast mutant screen as necessary for survival of polyploid cells, and also implicated in genome instability in human diseases including cancer. This points to commonalities across kingdoms and supports the hypothesis that selection has acted on genes controlling genome integrity in A. arenosa as an adaptive response to genome doubling.en_US
dc.description.sponsorshipOrganismic and Evolutionary Biologyen_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pgen.1003093en_US
dash.licenseLAA
dc.subjectadaptationen_US
dc.subjectgeneticsen_US
dc.subjectarabidposisen_US
dc.subjectchromosome segregationen_US
dc.subjectDNA methylationen_US
dc.subjectdiploidyen_US
dc.subjectplant genomeen_US
dc.subjectgenomic instabilityen_US
dc.subjectmeiosisen_US
dc.titleGenetic Adaptation Associated with Genome-Doubling in Autotetraploid Arabidopsis arenosaen_US
dc.typeJournal Articleen_US
dc.date.updated2013-07-03T19:41:25Z
dc.description.versionVersion of Recorden_US
dc.rights.holderHollister, J., Arnold, B., Svedin, E., Xue, K. Dilkes, B., Bomblies, K.
dc.relation.journalPLoS Geneticsen_US
dash.depositing.authorBomblies, Kirsten
dc.date.available2013-10-09T16:41:44Z
dc.identifier.doi10.1371/journal.pgen.1003093*
workflow.legacycommentsCCBY http://www.sherpa.ac.uk/romeo/issn/1553-7390/en_US
dash.contributor.affiliatedXue, Katherine
dash.contributor.affiliatedArnold, Brian
dash.contributor.affiliatedBomblies, Kirsten


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