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dc.contributor.advisorJackson-Grusby, Laurie Lynne
dc.contributor.authorYoo, Ronnie
dc.date.accessioned2013-10-15T00:54:06Z
dc.date.issued2013-10-14
dc.date.submitted2013
dc.identifier.citationYoo, Ronnie. 2013. Mechanisms of Stem Cell Regulation in Medulloblastoma. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11111en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11169777
dc.description.abstractMedulloblastoma, the most common pediatric malignant brain tumor, is comprised of a heterogeneous group of tumors with distinct molecular subtypes and clinical outcomes. In particular, tumors with a cancer stem cell (CSC) population have been observed to be more resistant to conventional therapies, necessitating the elucidation of pathways important in this population. Work in our lab has shown that neurosphere culture-enriched cells from Ptch1LacZ/+;Trp53-/- mouse medulloblastomas exhibit properties of self-renewal, expression of neural stem cell (NSC) markers and potent tumor-initiation. The pathway dependencies and mechanisms of self-renewal in these medulloblastoma neurospheres (MBNS) have not yet been characterized.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectOncologyen_US
dc.subjectDevelopmental biologyen_US
dc.subjectCerebellar Stem Cellsen_US
dc.subjectMedulloblastomaen_US
dc.subjectPatcheden_US
dc.subjectStem Cellsen_US
dc.titleMechanisms of Stem Cell Regulation in Medulloblastomaen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorYoo, Ronnie
dc.date.available2013-10-15T00:54:06Z
thesis.degree.date2013en_US
thesis.degree.disciplineBiology: Medical Sciences, Division ofen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberShivdasani, Rameshen_US
dc.contributor.committeeMemberLangenau, Daviden_US
dc.contributor.committeeMemberBreault, Daviden_US
dash.contributor.affiliatedYoo, Ronnie


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