Show simple item record

dc.contributor.advisorRuvkun, Gary B.
dc.contributor.authorShi, Zhen
dc.date.accessioned2013-10-15T13:39:57Z
dc.date.issued2013-10-15
dc.date.submitted2013
dc.identifier.citationShi, Zhen. 2013. Genetic and genomic analysis of small RNA pathways in nematodes. Doctoral dissertation, Harvard University.en_US
dc.identifier.otherhttp://dissertations.umi.com/gsas.harvard:11093en
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11169801
dc.description.abstractSmall noncoding RNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and endogenous small-interfering RNAs (endo-siRNAs), regulate developmental and defense pathways in animals. While many small RNA silencing protein cofactors have been identified, much more is to be learned from a dynamic and quantitative perspective to reveal the underlying mechanisms and designing principles of each pathway. In this dissertation, I present studies that examine the temporal dynamics of small RNA pathways - one from an evolutionary time scale among the nematode species, and one from finely staged Caenorabditis elegans during the first larval stage. I also describe works identifying new cofactors functions in the miRNA pathway, potentially through regulating the spatial dynamics of the miRNA silencing complex.en_US
dc.language.isoen_USen_US
dash.licenseLAA
dc.subjectGeneticsen_US
dc.subjectgeneticen_US
dc.subjectgenomicen_US
dc.subjectnematodesen_US
dc.subjectsmall RNAen_US
dc.titleGenetic and genomic analysis of small RNA pathways in nematodesen_US
dc.typeThesis or Dissertationen_US
dash.depositing.authorShi, Zhen
dc.date.available2013-10-15T13:39:57Z
thesis.degree.date2013en_US
thesis.degree.disciplineBiological Sciences in Dental Medicineen_US
thesis.degree.grantorHarvard Universityen_US
thesis.degree.leveldoctoralen_US
thesis.degree.namePh.D.en_US
dc.contributor.committeeMemberMoazed, Daneshen_US
dc.contributor.committeeMemberBlower, Michaelen_US
dc.contributor.committeeMemberVasudevan, Shobhaen_US
dc.contributor.committeeMemberWalhout, Marianen_US
dash.contributor.affiliatedShi, Zhen


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record