dc.contributor.advisor | Ruvkun, Gary B. | |
dc.contributor.author | Shi, Zhen | |
dc.date.accessioned | 2013-10-15T13:39:57Z | |
dc.date.issued | 2013-10-15 | |
dc.date.submitted | 2013 | |
dc.identifier.citation | Shi, Zhen. 2013. Genetic and genomic analysis of small RNA pathways in nematodes. Doctoral dissertation, Harvard University. | en_US |
dc.identifier.other | http://dissertations.umi.com/gsas.harvard:11093 | en |
dc.identifier.uri | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11169801 | |
dc.description.abstract | Small noncoding RNAs, including microRNAs (miRNAs), piwi-interacting RNAs (piRNAs), and endogenous small-interfering RNAs (endo-siRNAs), regulate developmental and defense pathways in animals. While many small RNA silencing protein cofactors have been identified, much more is to be learned from a dynamic and quantitative perspective to reveal the underlying mechanisms and designing principles of each pathway. In this dissertation, I present studies that examine the temporal dynamics of small RNA pathways - one from an evolutionary time scale among the nematode species, and one from finely staged Caenorabditis elegans during the first larval stage. I also describe works identifying new cofactors functions in the miRNA pathway, potentially through regulating the spatial dynamics of the miRNA silencing complex. | en_US |
dc.language.iso | en_US | en_US |
dash.license | LAA | |
dc.subject | Genetics | en_US |
dc.subject | genetic | en_US |
dc.subject | genomic | en_US |
dc.subject | nematodes | en_US |
dc.subject | small RNA | en_US |
dc.title | Genetic and genomic analysis of small RNA pathways in nematodes | en_US |
dc.type | Thesis or Dissertation | en_US |
dash.depositing.author | Shi, Zhen | |
dc.date.available | 2013-10-15T13:39:57Z | |
thesis.degree.date | 2013 | en_US |
thesis.degree.discipline | Biological Sciences in Dental Medicine | en_US |
thesis.degree.grantor | Harvard University | en_US |
thesis.degree.level | doctoral | en_US |
thesis.degree.name | Ph.D. | en_US |
dc.contributor.committeeMember | Moazed, Danesh | en_US |
dc.contributor.committeeMember | Blower, Michael | en_US |
dc.contributor.committeeMember | Vasudevan, Shobha | en_US |
dc.contributor.committeeMember | Walhout, Marian | en_US |
dash.contributor.affiliated | Shi, Zhen | |