Extending Coalescent Theory to Autotetraploids

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Extending Coalescent Theory to Autotetraploids

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Title: Extending Coalescent Theory to Autotetraploids
Author: Arnold, Brian John; Bomblies, Kirsten; Wakeley, John

Note: Order does not necessarily reflect citation order of authors.

Citation: Arnold, B., K. Bomblies, and J. Wakeley. 2012. Extending coalescent theory to autotetraploids. Genetics 192(1): 195-204.
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Abstract: We develop coalescent models for autotetraploid species with tetrasomic inheritance. We show that the ancestral genetic process in a large population without recombination may be approximated using Kingman’s standard coalescent, with a coalescent effective population size 4N. Numerical results suggest that this approximation is accurate for population sizes on the order of hundreds of individuals. Therefore, existing coalescent simulation programs can be adapted to study population history in autotetraploids simply by interpreting the timescale in units of 4N generations. We also consider the possibility of double reduction, a phenomenon unique to polysomic inheritance, and show that its effects on gene genealogies are similar to partial self-fertilization.
Published Version: doi:10.1534/genetics.112.140582
Other Sources: http://www.oeb.harvard.edu/faculty/wakeley/john/Reprints/ArnoldEtAl2012.pdf
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11169804
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