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dc.contributor.authorCherry, Jonathan D.
dc.contributor.authorLiu, Bin
dc.contributor.authorFrost, Jeffrey L.
dc.contributor.authorLemere, Cynthia Ann
dc.contributor.authorWilliams, Jacqueline P.
dc.contributor.authorOlschowka, John A.
dc.contributor.authorO’Banion, M. Kerry
dc.date.accessioned2013-10-16T13:51:40Z
dc.date.issued2012
dc.identifier.citationCherry, Jonathan D., Bin Liu, Jeffrey L. Frost, Cynthia A. Lemere, Jacqueline P. Williams, John A. Olschowka, and M. Kerry O’Banion. 2012. Galactic cosmic radiation leads to cognitive impairment and increased Aβ plaque accumulation in a mouse model of Alzheimer’s disease. PLoS ONE 7(12): e53275.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11177899
dc.description.abstractGalactic Cosmic Radiation consisting of high-energy, high-charged (HZE) particles poses a significant threat to future astronauts in deep space. Aside from cancer, concerns have been raised about late degenerative risks, including effects on the brain. In this study we examined the effects of \(^{56}\)Fe particle irradiation in an APP/PS1 mouse model of Alzheimer’s disease (AD). We demonstrated 6 months after exposure to 10 and 100 cGy \(^{56}\)Fe radiation at 1 GeV/µ, that APP/PS1 mice show decreased cognitive abilities measured by contextual fear conditioning and novel object recognition tests. Furthermore, in male mice we saw acceleration of Aβ plaque pathology using Congo red and 6E10 staining, which was further confirmed by ELISA measures of Aβ isoforms. Increases were not due to higher levels of amyloid precursor protein (APP) or increased cleavage as measured by levels of the β C-terminal fragment of APP. Additionally, we saw no change in microglial activation levels judging by CD68 and Iba-1 immunoreactivities in and around Aβ plaques or insulin degrading enzyme, which has been shown to degrade Aβ. However, immunohistochemical analysis of ICAM-1 showed evidence of endothelial activation after 100 cGy irradiation in male mice, suggesting possible alterations in Aβ trafficking through the blood brain barrier as a possible cause of plaque increase. Overall, our results show for the first time that HZE particle radiation can increase Aβ plaque pathology in an APP/PS1 mouse model of AD.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0053275en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3534034/pdf/en_US
dash.licenseLAA
dc.subjectAstronomical Sciencesen_US
dc.subjectSpace Explorationen_US
dc.subjectMars Exploration Programen_US
dc.subjectSpace Missionsen_US
dc.subjectBiologyen_US
dc.subjectModel Organismsen_US
dc.subjectAnimal Modelsen_US
dc.subjectMouseen_US
dc.subjectNeuroscienceen_US
dc.subjectLearning and Memoryen_US
dc.subjectNeurobiology of Disease and Regenerationen_US
dc.subjectRadiobiologyen_US
dc.subjectMedicineen_US
dc.subjectNeurologyen_US
dc.subjectDementiaen_US
dc.subjectAlzheimer Diseaseen_US
dc.titleGalactic Cosmic Radiation Leads to Cognitive Impairment and Increased Aβ Plaque Accumulation in a Mouse Model of Alzheimer’s Diseaseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorLemere, Cynthia Ann
dc.date.available2013-10-16T13:51:40Z
dc.identifier.doi10.1371/journal.pone.0053275*
dash.contributor.affiliatedLemere, Cynthia


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