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dc.contributor.authorLevy, Bruce David
dc.date.accessioned2013-10-16T14:08:05Z
dc.date.issued2012
dc.identifier.citationLevy, Bruce D. 2012. Resolvin D1 and resolvin E1 promote the resolution of allergic airway inflammation via shared and distinct molecular counter-regulatory pathways. Frontiers in Immunology 3:390.en_US
dc.identifier.issn1664-3224en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11177915
dc.description.abstractResolvins are generated from omega-3 fatty acids during inflammatory responses in the lung. These natural mediators interact with specific receptors to decrease lung inflammation and promote its resolution in healthy tissues. There are several lung diseases of chronic inflammation that fail to resolve, most notable asthma. This common disorder has a lifetime prevalence of nearly 10% and is characterized, in part, by chronic, non-resolving inflammation of the airway. Pro-resolving mediators are generated during asthma; however, their biosynthesis is decreased in severe and uncontrolled asthma, suggesting that the chronic, adaptive inflammation in asthmatic airways may result from a resolution defect. This article focuses on recent insights into the cellular and molecular mechanisms for resolvins that limit adaptive immune responses in healthy airways.en_US
dc.language.isoen_USen_US
dc.publisherFrontiers Media S.A.en_US
dc.relation.isversionofdoi:10.3389/fimmu.2012.00390en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3531584/pdf/en_US
dash.licenseLAA
dc.subjectReview Articleen_US
dc.subjectresolutionen_US
dc.subjectresolvinsen_US
dc.subjectinflammationen_US
dc.subjectlungen_US
dc.subjectasthmaen_US
dc.titleResolvin D1 and Resolvin E1 Promote the Resolution of Allergic Airway Inflammation via Shared and Distinct Molecular Counter-Regulatory Pathwaysen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalFrontiers in Immunologyen_US
dash.depositing.authorLevy, Bruce David
dc.date.available2013-10-16T14:08:05Z
dc.identifier.doi10.3389/fimmu.2012.00390*
dash.contributor.affiliatedLevy, Bruce


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