Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection

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Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection

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Title: Loss of CD103+ DCs and Mucosal IL-17+ and IL-22+ Lymphocytes is Associated with Mucosal Damage in SIV Infection
Author: Klatt, Nichole R.; Estes, Jacob D.; Sun, Xiaoyong; Ortiz, Alexandra M.; Barber, John S.; Harris, Levelle D.; Cervasi, Barbara; Yokomizo, Lauren K.; Pan, Li; Vinton, Carol L.; Tabb, Brian; Canary, Lauren A.; Dang, Que; Hirsch, Vanessa M.; Alter, Galit; Belkaid, Yasmine; Lifson, Jeffrey D.; Silvestri, Guido; Milner, Joshua D.; Paiardini, Mirko; Haddad, Elias K.; Brenchley, Jason M.

Note: Order does not necessarily reflect citation order of authors.

Citation: Klatt, Nichole R., Jacob D. Estes, Xiaoyong Sun, Alexandra M. Ortiz, John S. Barber, Levelle D. Harris, Barbara Cervasi, et al. 2012. Loss of CD103+ DCs and mucosal IL-17+ and IL-22+ lymphocytes is associated with mucosal damage in SIV infection. Mucosal immunology 5(6): 646-657.
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Abstract: HIV/SIV disease progression is associated with multifocal damage to the GI tract epithelial barrier that correlates with microbial translocation and persistent pathological immune activation but the underlying mechanisms remain unclear. Investigating alterations in mucosal immunity during SIV infection, we found that damage to the colonic epithelial barrier was associated with loss of multiple lineages of IL-17-producing lymphocytes, cells that microarray analysis showed express genes important for enterocyte homeostasis, including IL-22. IL-22-producing lymphocytes were also lost after SIV infection. Potentially explaining coordinate loss of these distinct populations, we also observed loss of CD103+ DCs after SIV infection which associated with loss of IL-17 and IL-22-producing lymphocytes. CD103+ DCs expressed genes associated with promotion of IL-17/IL-22+ cells, and co-culture of CD103+ DCs and naïve T-cells led to increased IL17A and RORc expression in differentiating T-cells. These results reveal complex interactions between mucosal immune cell subsets providing potential mechanistic insights into mechanisms of mucosal immune dysregulation during HIV/SIV infection, and offer hints for development of novel therapeutic strategies to address this aspect of AIDS virus pathogenesis.
Published Version: doi:10.1038/mi.2012.38
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3443541/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11177926
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