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dc.contributor.authorKoltsida, Ourania
dc.contributor.authorKaramnov, Sergey
dc.contributor.authorPyrillou, Katerina
dc.contributor.authorVickery, Thad
dc.contributor.authorChairakaki, Aikaterini-Dimitra
dc.contributor.authorTamvakopoulos, Constantin
dc.contributor.authorSideras, Paschalis
dc.contributor.authorSerhan, Charles Nicholas
dc.contributor.authorAndreakos, Evangelos
dc.date.accessioned2013-10-16T14:54:14Z
dc.date.issued2013
dc.identifier.citationKoltsida, Ourania, Sergey Karamnov, Katerina Pyrillou, Thad Vickery, Aikaterini-Dimitra Chairakaki, Constantin Tamvakopoulos, Paschalis Sideras, Charles N Serhan, and Evangelos Andreakos. 2013. Toll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammation. EMBO Molecular Medicine 5(5): 762-775.en_US
dc.identifier.issn1757-4676en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11177931
dc.description.abstractAlthough specialized pro-resolving mediators (SPMs) biosynthesized from polyunsaturated fatty acids are critical for the resolution of acute inflammation, the molecules and pathways that induce their production remain elusive. Here, we show that TLR7, a receptor recognizing viral ssRNA and damaged self-RNA, mobilizes the docosahexaenoic acid (DHA)-derived biosynthetic pathways that lead to the generation of D-series SPMs. In mouse macrophages and human monocytes, TLR7 activation triggered production of DHA-derived monohydroxy metabolome markers and generation of protectin D1 (PD1) and resolvin D1 (RvD1). In mouse allergic airway inflammation, TLR7 activation enhanced production of DHA-derived SPMs including PD1 and accelerated the catabasis of Th2-mediated inflammation. D-series SPMs were critical for TLR7-mediated resolution of airway inflammation as this effect was lost in Alox15−/− mice, while resolution was enhanced after local administration of PD1 or RvD1. Together, our findings reveal a new previously unsuspected role of TLR7 in the generation of D-series SPMs and the resolution of allergic airway inflammation. They also identify TLR stimulation as a new approach to drive SPMs and resolution of inflammatory diseases.en_US
dc.language.isoen_USen_US
dc.publisherWILEY-VCH Verlagen_US
dc.relation.isversionofdoi:10.1002/emmm.201201891en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3662318/pdf/en_US
dash.licenseLAA
dc.subjectairway inflammationen_US
dc.subjectpolyunsaturated fatty aciden_US
dc.subjectresolution of inflammationen_US
dc.subjectspecialized pro-resolving mediatoren_US
dc.subjectToll-like receptoren_US
dc.titleToll-like receptor 7 stimulates production of specialized pro-resolving lipid mediators and promotes resolution of airway inflammationen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalEMBO Molecular Medicineen_US
dash.depositing.authorSerhan, Charles Nicholas
dc.date.available2013-10-16T14:54:14Z
dc.identifier.doi10.1002/emmm.201201891*
dash.contributor.affiliatedKaramnov, Sergey
dash.contributor.affiliatedSerhan, Charles


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