Potential for therapeutic manipulation of the UPR in disease

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Potential for therapeutic manipulation of the UPR in disease

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Title: Potential for therapeutic manipulation of the UPR in disease
Author: Park, Sang Won; Ozcan, Umut

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Citation: Park, Sang Won, and Umut Ozcan. 2013. Potential for therapeutic manipulation of the UPR in disease. Seminars in Immunopathology 35(3): 351-373.
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Abstract: Increased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions. The UPR normally protects cells and re-establishes cellular homeostasis, but prolonged UPR activation can lead to the development of various pathologies. These features make the UPR signaling pathway an attractive target for the treatment of diseases whose pathogenesis is characterized by chronic activation of this pathway. Here, we focus on the molecular signaling pathways of the UPR and suggest possible ways to target this response for therapeutic purposes.
Published Version: doi:10.1007/s00281-013-0370-z
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641308/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11177951
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