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dc.contributor.authorPark, Sang Won
dc.contributor.authorOzcan, Umut
dc.date.accessioned2013-10-16T15:22:00Z
dc.date.issued2013
dc.identifier.citationPark, Sang Won, and Umut Ozcan. 2013. Potential for therapeutic manipulation of the UPR in disease. Seminars in Immunopathology 35(3): 351-373.en_US
dc.identifier.issn1863-2297en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11177951
dc.description.abstractIncreased endoplasmic reticulum (ER) stress and the activated unfolded protein response (UPR) signaling associated with it play key roles in physiological processes as well as under pathological conditions. The UPR normally protects cells and re-establishes cellular homeostasis, but prolonged UPR activation can lead to the development of various pathologies. These features make the UPR signaling pathway an attractive target for the treatment of diseases whose pathogenesis is characterized by chronic activation of this pathway. Here, we focus on the molecular signaling pathways of the UPR and suggest possible ways to target this response for therapeutic purposes.en_US
dc.language.isoen_USen_US
dc.publisherSpringer-Verlagen_US
dc.relation.isversionofdoi:10.1007/s00281-013-0370-zen_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641308/pdf/en_US
dash.licenseLAA
dc.subjectEndoplasmic reticulum (ER) stressen_US
dc.subjectChemical chaperoneen_US
dc.subjectXBP1en_US
dc.subjectInsulin resistanceen_US
dc.subjectType 2 diabetesen_US
dc.titlePotential for therapeutic manipulation of the UPR in diseaseen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalSeminars in Immunopathologyen_US
dash.depositing.authorOzcan, Umut
dc.date.available2013-10-16T15:22:00Z
dc.identifier.doi10.1007/s00281-013-0370-z*
dash.contributor.affiliatedPark, Sang Won
dash.contributor.affiliatedOzcan, Umut


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