Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel?

DSpace/Manakin Repository

Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel?

Citable link to this page

 

 
Title: Acute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel?
Author: Sahin, Afsun; Hamrah, Pedram

Note: Order does not necessarily reflect citation order of authors.

Citation: Sahin, Afsun, and Pedram Hamrah. 2012. Acute herpetic keratitis: what is the role for ganciclovir ophthalmic gel? Ophthalmology and Eye Diseases 4: 23-34.
Full Text & Related Files:
Abstract: Herpes simplex keratitis (HSK) is a major cause of corneal blindness in the world. Following the primary infection, the virus enters into a latent phase. Recurrent infectious or immune keratitis cause structural damage to the cornea, scarring, and may lead to blindness. Several commercially available topical and oral antiviral drugs for HSK are currently available. However, toxicity and low patient compliance hamper their use in HSK. Further, oral antiviral drugs alone are not always effective in HSK. Thus, there had been a need for safe and effective topical antiviral agents against HSK. Systemic ganciclovir has been in use for the treatment of cytomegalovirus infections. Recently, topical ganciclovir has become available for use in patients with HSK. Ganciclovir 0.15% ophthalmic gel has been shown to be both safe and effective against viruses of the herpes family. Topical ganciclovir ophthalmic gel is well tolerated and does not cause significant toxic effects on the ocular surface. Several multicenter studies have revealed the potential role of ganciclovir ophthalmic gel in the treatment and prophylaxis of epithelial HSK. In this paper, we have reviewed the pharmacology, efficacy, side effects, and the role of ganciclovir ophthalmic gel 0.15% in the treatment of acute herpetic keratitis.
Published Version: doi:10.4137/OED.S7267
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619435/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11178961
Downloads of this work:

Show full Dublin Core record

This item appears in the following Collection(s)

 
 

Search DASH


Advanced Search
 
 

Submitters