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dc.contributor.authorSahin, Afsun
dc.contributor.authorHamrah, Pedram
dc.date.accessioned2013-10-16T17:14:38Z
dc.date.issued2012
dc.identifier.citationSahin, Afsun, and Pedram Hamrah. 2012. Acute herpetic keratitis: what is the role for ganciclovir ophthalmic gel? Ophthalmology and Eye Diseases 4: 23-34.en_US
dc.identifier.issn1179-1721en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11178961
dc.description.abstractHerpes simplex keratitis (HSK) is a major cause of corneal blindness in the world. Following the primary infection, the virus enters into a latent phase. Recurrent infectious or immune keratitis cause structural damage to the cornea, scarring, and may lead to blindness. Several commercially available topical and oral antiviral drugs for HSK are currently available. However, toxicity and low patient compliance hamper their use in HSK. Further, oral antiviral drugs alone are not always effective in HSK. Thus, there had been a need for safe and effective topical antiviral agents against HSK. Systemic ganciclovir has been in use for the treatment of cytomegalovirus infections. Recently, topical ganciclovir has become available for use in patients with HSK. Ganciclovir 0.15% ophthalmic gel has been shown to be both safe and effective against viruses of the herpes family. Topical ganciclovir ophthalmic gel is well tolerated and does not cause significant toxic effects on the ocular surface. Several multicenter studies have revealed the potential role of ganciclovir ophthalmic gel in the treatment and prophylaxis of epithelial HSK. In this paper, we have reviewed the pharmacology, efficacy, side effects, and the role of ganciclovir ophthalmic gel 0.15% in the treatment of acute herpetic keratitis.en_US
dc.language.isoen_USen_US
dc.publisherLibertas Academicaen_US
dc.relation.isversionofdoi:10.4137/OED.S7267en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3619435/pdf/en_US
dash.licenseLAA
dc.subjectherpes simplexen_US
dc.subjectgancicloviren_US
dc.subjectantiviralen_US
dc.subjectkeratitisen_US
dc.subjectherpeticen_US
dc.titleAcute Herpetic Keratitis: What is the Role for Ganciclovir Ophthalmic Gel?en_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalOphthalmology and Eye Diseasesen_US
dash.depositing.authorHamrah, Pedram
dc.date.available2013-10-16T17:14:38Z
dc.identifier.doi10.4137/OED.S7267*
dash.contributor.affiliatedHamrah, Pedram


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