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dc.contributor.authorSzentkirályi, András
dc.contributor.authorWinter, Anke C
dc.contributor.authorSchürks, Markus
dc.contributor.authorVölzke, Henry
dc.contributor.authorHoffmann, Wolfgang
dc.contributor.authorBuring, Julie Elizabeth
dc.contributor.authorGaziano, John Michael
dc.contributor.authorKurth, Tobias
dc.contributor.authorBerger, Klaus
dc.date.accessioned2013-10-16T18:03:36Z
dc.date.issued2012
dc.identifier.citationSzentkirályi, András, Anke C. Winter, Markus Schürks, Henry Völzke, Wolfgang Hoffmann, Julie E. Buring, J. Michael Gaziano, Tobias Kurth, and Klaus Berger. 2012. Restless legs syndrome and all-cause mortality in four prospective cohort studies. BMJ Open 2(6): e001652.en_US
dc.identifier.issn2044-6055en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11179042
dc.description.abstractObjectives: To evaluate the association between restless legs syndrome (RLS) and all-cause mortality. Design: Four prospective cohort studies. Setting: The Dortmund Health Study (DHS) and the Study of Health in Pomerania (SHIP) from Germany. The Women's Health Study (WHS) and the Physicians’ Health Study (PHS) from the USA. Participants: In DHS: a random sample (n=1 299) from the population of Dortmund; in SHIP: a sample (n=4 291) from residents living in West Pomerania were drawn by multistage random sampling design; in WHS: female healthcare professionals (n=31 370); in PHS: male physicians (n=22 926) Main outcome measures: All-cause mortality. Results: The prevalence of RLS ranged between 7.4% and 11.9% at baseline. During follow-up (ranging between 6 and 11 years) RLS was not associated with increased risk of all-cause mortality in any of the four cohorts. The multivariable-adjusted HRs (95% CI) for all-cause mortality ranged from 0.21 (0.03 to 1.53) to 1.07 (0.93 to 1.23) across the four studies. The HRs for all-cause mortality did not differ according to gender. Conclusions: In these four independently conducted large prospective cohort studies from Germany and the USA, RLS did not increase the risk of all-cause mortality. These findings do not support the hypothesis that RLS is a risk factor for mortality of any cause.en_US
dc.language.isoen_USen_US
dc.publisherBMJ Groupen_US
dc.relation.isversionofdoi:10.1136/bmjopen-2012-001652en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533015/pdf/en_US
dash.licenseLAA
dc.subjectrestless legs sydromeen_US
dc.subjectprospective cohort studyen_US
dc.subjectmortalityen_US
dc.titleRestless Legs Syndrome and All-Cause Mortality in Four Prospective Cohort Studiesen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalBMJ Openen_US
dash.depositing.authorGaziano, John Michael
dc.date.available2013-10-16T18:03:36Z
dc.identifier.doi10.1136/bmjopen-2012-001652*
dash.contributor.affiliatedBuring, Julie
dash.contributor.affiliatedKurth, Tobias
dash.contributor.affiliatedGaziano, John


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