New players on the metabolic stage

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New players on the metabolic stage

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Title: New players on the metabolic stage
Author: Cohen, David E
Citation: Cohen, David E. 2013. New players on the metabolic stage. Adipocyte 2(1): 3-6.
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Abstract: Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly upregulated when mice are exposed to cold ambient temperatures. In a recent study, we demonstrated that Them1−/− mice exhibit increased energy expenditure and are resistant to diet-induced obesity and its metabolic consequences. This mini-review places these findings in the context of an emerging understanding of Them/Acot genes.
Published Version: doi:10.4161/adip.21853
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