Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders

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Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders

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Title: Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders
Author: Nelson, Tristan; Jung, Jae-Yoon; DeLuca, Todd; Hinebaugh, Byron Kent; St Gabriel, Kristian Che; Wall, Dennis Paul Paul

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Citation: Nelson, Tristan H., Jae-Yoon Jung, Todd F. DeLuca, Byron K. Hinebaugh, Kristian Che St. Gabriel, and Dennis P. Wall. 2012. Autworks: a cross-disease network biology application for autism and related disorders. BMC Medical Genomics 5: 56.
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Abstract: Background: The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results. Description: We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis. Conclusions: Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders.
Published Version: doi:10.1186/1755-8794-5-56
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533944/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11179047
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