Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders
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Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders
| Title: | Autworks: a Cross-Disease Network Biology Application for Autism and Related Disorders |
| Author: |
Nelson, Tristan; Jung, Jae-Yoon; DeLuca, Todd; Hinebaugh, Byron Kent; St Gabriel, Kristian Che; Wall, Dennis Paul Paul
Note: Order does not necessarily reflect citation order of authors. |
| Citation: | Nelson, Tristan H., Jae-Yoon Jung, Todd F. DeLuca, Byron K. Hinebaugh, Kristian Che St. Gabriel, and Dennis P. Wall. 2012. Autworks: a cross-disease network biology application for autism and related disorders. BMC Medical Genomics 5: 56. |
| Full Text & Related Files: |
3533944.pdf (309.4Kb; PDF) 
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| Abstract: | Background: The genetic etiology of autism is heterogeneous. Multiple disorders share genotypic and phenotypic traits with autism. Network based cross-disorder analysis can aid in the understanding and characterization of the molecular pathology of autism, but there are few tools that enable us to conduct cross-disorder analysis and to visualize the results. Description: We have designed Autworks as a web portal to bring together gene interaction and gene-disease association data on autism to enable network construction, visualization, network comparisons with numerous other related neurological conditions and disorders. Users may examine the structure of gene interactions within a set of disorder-associated genes, compare networks of disorder/disease genes with those of other disorders/diseases, and upload their own sets for comparative analysis. Conclusions: Autworks is a web application that provides an easy-to-use resource for researchers of varied backgrounds to analyze the autism gene network structure within and between disorders. |
| Published Version: | doi:10.1186/1755-8794-5-56 |
| Other Sources: | http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3533944/pdf/ |
| Terms of Use: | This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA |
| Citable link to this page: | http://nrs.harvard.edu/urn-3:HUL.InstRepos:11179047 |
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