Evaluation and Correction for Optical Scattering Variations in Laser Speckle Rheology of Biological Fluids

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Evaluation and Correction for Optical Scattering Variations in Laser Speckle Rheology of Biological Fluids

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Title: Evaluation and Correction for Optical Scattering Variations in Laser Speckle Rheology of Biological Fluids
Author: Hajjarian, Zeinab; Nadkarni, Seemantini

Note: Order does not necessarily reflect citation order of authors.

Citation: Hajjarian, Zeinab, and Seemantini K. Nadkarni. 2013. Evaluation and correction for optical scattering variations in laser speckle rheology of biological fluids. PLoS ONE 8(5): e65014.
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Abstract: Biological fluids fulfill key functionalities such as hydrating, protecting, and nourishing cells and tissues in various organ systems. They are capable of these versatile tasks owing to their distinct structural and viscoelastic properties. Characterizing the viscoelastic properties of bio-fluids is of pivotal importance for monitoring the development of certain pathologies as well as engineering synthetic replacements. Laser Speckle Rheology (LSR) is a novel optical technology that enables mechanical evaluation of tissue. In LSR, a coherent laser beam illuminates the tissue and temporal speckle intensity fluctuations are analyzed to evaluate mechanical properties. The rate of temporal speckle fluctuations is, however, influenced by both optical and mechanical properties of tissue. Therefore, in this paper, we develop and validate an approach to estimate and compensate for the contributions of light scattering to speckle dynamics and demonstrate the capability of LSR for the accurate extraction of viscoelastic moduli in phantom samples and biological fluids of varying optical and mechanical properties.
Published Version: doi:10.1371/journal.pone.0065014
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3660338/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11179743
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