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dc.contributor.authorBhasin, Manoj
dc.contributor.authorDusek, Jeffery A.
dc.contributor.authorChang, Bei-Hung
dc.contributor.authorJoseph, Marie G.
dc.contributor.authorDenninger, John Weber
dc.contributor.authorFricchione, Gregory Lewis
dc.contributor.authorBenson, Herbert
dc.contributor.authorLibermann, Towia Aron
dc.date.accessioned2013-10-16T19:10:42Z
dc.date.issued2013
dc.identifier.citationBhasin, Manoj K., Jeffery A. Dusek, Bei-Hung Chang, Marie G. Joseph, John W. Denninger, Gregory L. Fricchione, Herbert Benson, and Towia A. Libermann. 2013. Relaxation response induces temporal transcriptome changes in energy metabolism, insulin secretion and inflammatory pathways. PLoS ONE 8(5): e62817.en_US
dc.identifier.issn1932-6203en_US
dc.identifier.urihttp://nrs.harvard.edu/urn-3:HUL.InstRepos:11179744
dc.description.abstractThe relaxation response (RR) is the counterpart of the stress response. Millennia-old practices evoking the RR include meditation, yoga and repetitive prayer. Although RR elicitation is an effective therapeutic intervention that counteracts the adverse clinical effects of stress in disorders including hypertension, anxiety, insomnia and aging, the underlying molecular mechanisms that explain these clinical benefits remain undetermined. To assess rapid time-dependent (temporal) genomic changes during one session of RR practice among healthy practitioners with years of RR practice and also in novices before and after 8 weeks of RR training, we measured the transcriptome in peripheral blood prior to, immediately after, and 15 minutes after listening to an RR-eliciting or a health education CD. Both short-term and long-term practitioners evoked significant temporal gene expression changes with greater significance in the latter as compared to novices. RR practice enhanced expression of genes associated with energy metabolism, mitochondrial function, insulin secretion and telomere maintenance, and reduced expression of genes linked to inflammatory response and stress-related pathways. Interactive network analyses of RR-affected pathways identified mitochondrial ATP synthase and insulin (INS) as top upregulated critical molecules (focus hubs) and NF-κB pathway genes as top downregulated focus hubs. Our results for the first time indicate that RR elicitation, particularly after long-term practice, may evoke its downstream health benefits by improving mitochondrial energy production and utilization and thus promoting mitochondrial resiliency through upregulation of ATPase and insulin function. Mitochondrial resiliency might also be promoted by RR-induced downregulation of NF-κB-associated upstream and downstream targets that mitigates stress.en_US
dc.language.isoen_USen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.isversionofdoi:10.1371/journal.pone.0062817en_US
dc.relation.hasversionhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC3641112/pdf/en_US
dash.licenseLAA
dc.subjectBiologyen_US
dc.subjectAnatomy and Physiologyen_US
dc.subjectPhysiological Processesen_US
dc.subjectEnergy Metabolismen_US
dc.subjectBiochemistryen_US
dc.subjectBioenergeticsen_US
dc.subjectEnergy-Producing Organellesen_US
dc.subjectComputational Biologyen_US
dc.subjectGenomicsen_US
dc.subjectGenome Analysis Toolsen_US
dc.subjectTranscriptomesen_US
dc.subjectMolecular Cell Biologyen_US
dc.subjectSignal Transductionen_US
dc.subjectSignaling Cascadesen_US
dc.subjectInsulin Signaling Cascadeen_US
dc.titleRelaxation Response Induces Temporal Transcriptome Changes in Energy Metabolism, Insulin Secretion and Inflammatory Pathwaysen_US
dc.typeJournal Articleen_US
dc.description.versionVersion of Recorden_US
dc.relation.journalPLoS ONEen_US
dash.depositing.authorLibermann, Towia Aron
dc.date.available2013-10-16T19:10:42Z
dc.identifier.doi10.1371/journal.pone.0062817*
dash.contributor.affiliatedFricchione, Gregory
dash.contributor.affiliatedDenninger, John
dash.contributor.affiliatedBenson, Herbert
dash.contributor.affiliatedBhasin, Manoj
dash.contributor.affiliatedLibermann, Towia


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