Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics

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Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics

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Title: Hypertrophic cardiomyopathy: Translating cellular cross talk into therapeutics
Author: Teekakirikul, Polakit; Padera, Robert Francis; Seidman, Jonathan G.; Seidman, Christine Edry

Note: Order does not necessarily reflect citation order of authors.

Citation: Teekakirikul, Polakit, Robert F. Padera, J.G. Seidman, and Christine E. Seidman. 2012. Hypertrophic cardiomyopathy: translating cellular cross talk into therapeutics. The Journal of Cell Biology 199(3): 417-421.
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Abstract: Hypertrophic cardiomyopathy (HCM) is a common inherited heart disease with serious adverse outcomes, including heart failure, arrhythmias, and sudden cardiac death. The discovery that mutations in sarcomere protein genes cause HCM has enabled the development of mouse models that recapitulate clinical manifestations of disease. Studies in these models have provided unexpected insights into the biophysical and biochemical properties of mutated contractile proteins and may help to improve clinical diagnosis and management of patients with HCM.
Published Version: doi:10.1083/jcb.201207033
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3483129/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11179749
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