# Bioenergetic Measurements in Children with Bipolar Disorder: A Pilot $$^{31}$$P Magnetic Resonance Spectroscopy Study

 Title: Bioenergetic Measurements in Children with Bipolar Disorder: A Pilot $$^{31}$$P Magnetic Resonance Spectroscopy Study Author: Sikoglu, Elif M.; Jensen, John Eric; Vitaliano, Gordana Dragan; Liso Navarro, Ana A.; Renshaw, Perry Franklin; Frazier, Jean A.; Moore, Constance M. Note: Order does not necessarily reflect citation order of authors. Citation: Sikoglu, Elif M., J. Eric Jensen, Gordana Vitaliano, Ana A. Liso Navarro, Perry F. Renshaw, Jean A. Frazier, and Constance M. Moore. 2013. Bioenergetic measurements in children with bipolar disorder: a pilot $$^{31}$$P magnetic resonance spectroscopy study. PLoS ONE 8(1): e54536. Full Text & Related Files: 3559786.pdf (402.5Kb; PDF) Abstract: Background: Research exploring Bipolar Disorder (BD) phenotypes and mitochondrial dysfunction, particularly in younger subjects, has been insufficient to date. Previous studies have found abnormal cerebral pH levels in adults with BD, which may be directly linked to abnormal mitochondrial activity. To date no such studies have been reported in children with BD. Methods: Phosphorus Magnetic Resonance Spectroscopy ($$^{31}$$P MRS) was used to determine pH, phopshocreatine (PCr) and inorganic phosphate (Pi) levels in 8 subjects with BD and 8 healthy comparison subjects (HCS) ages 11 to 20 years old. Results: There was no significant difference in pH between the patients and HCS. However, frontal pH values for patients with BD increased with age, contrary to studies of HCS and the pH values in the frontal lobe correlated negatively with the YMRS values. Global Pi was significantly lower in subjects with BD compared with HCS. There were no significant differences in PCr between the groups. Global PCr-to-Pi ratio (PCr/Pi) was significantly higher in subjects with BD compared with HCS. Conclusions: The change in Pi levels for the patients with BD coupled with the no difference in PCr levels, suggest an altered mitochondrial phosphorylation. However, our findings require further investigation of the underlying mechanisms with the notion that a mitochondrial dysfunction may manifest itself differently in children than that in adults. Limitations: Further investigations with larger patient populations are necessary to draw further conclusions. Published Version: doi:10.1371/journal.pone.0054536 Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3559786/pdf/ Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11179753 Downloads of this work: