Assessment of axial bone rigidity in rats with metabolic diseases using CT-based structural rigidity analysis

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Assessment of axial bone rigidity in rats with metabolic diseases using CT-based structural rigidity analysis

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Title: Assessment of axial bone rigidity in rats with metabolic diseases using CT-based structural rigidity analysis
Author: Smith, M. D.; Baldassarri, S.; Anez-Bustillos, L.; Tseng, A.; Entezari, V.; Zurakowski, David; Snyder, Brian Dale; Nazarian, Ara

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Citation: Smith, M. D., S. Baldassarri, L. Anez-Bustillos, A. Tseng, V. Entezari, D. Zurakowski, B. D. Snyder, and A. Nazarian. 2012. Assessment of axial bone rigidity in rats with metabolic diseases using CT-based structural rigidity analysis. Bone & Joint Research 1(2): 13-19.
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Abstract: Objectives: This study aims to assess the correlation of CT-based structural rigidity analysis with mechanically determined axial rigidity in normal and metabolically diseased rat bone. Methods: A total of 30 rats were divided equally into normal, ovariectomized, and partially nephrectomized groups. Cortical and trabecular bone segments from each animal underwent micro-CT to assess their average and minimum axial rigidities using structural rigidity analysis. Following imaging, all specimens were subjected to uniaxial compression and assessment of mechanically-derived axial rigidity. Results: The average structural rigidity-based axial rigidity was well correlated with the average mechanically-derived axial rigidity results (R\(^2\) = 0.74). This correlation improved significantly (p < 0.0001) when the CT-based Structural Rigidity Analysis (CTRA) minimum axial rigidity was correlated to the mechanically-derived minimum axial rigidity results (R\(^2\) = 0.84). Tests of slopes in the mixed model regression analysis indicated a significantly steeper slope for the average axial rigidity compared with the minimum axial rigidity (p = 0.028) and a significant difference in the intercepts (p = 0.022). The CTRA average and minimum axial rigidities were correlated with the mechanically-derived average and minimum axial rigidities using paired t-test analysis (p = 0.37 and p = 0.18, respectively). Conclusions: In summary, the results of this study suggest that structural rigidity analysis of micro-CT data can be used to accurately and quantitatively measure the axial rigidity of bones with metabolic pathologies in an experimental rat model. It appears that minimum axial rigidity is a better model for measuring bone rigidity than average axial rigidity.
Published Version: doi:10.1302/2046-3758.12.2000021
Other Sources: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3626191/pdf/
Terms of Use: This article is made available under the terms and conditions applicable to Other Posted Material, as set forth at http://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAA
Citable link to this page: http://nrs.harvard.edu/urn-3:HUL.InstRepos:11179755
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